Crisnatol mesylate

Modify Date: 2024-01-05 12:35:02

Crisnatol mesylate structure	Common Name	Crisnatol mesylate
	CAS Number	96389-69-4	Molecular Weight	441.54000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₇NO₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Crisnatol mesylate

Crisnatol (BWA770U) mesylate is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol mesylate shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts[1][2][3].

Name	2-(chrysen-6-ylmethylamino)-2-methylpropane-1,3-diol,methanesulfonic acid
Synonym	More Synonyms

Description	Crisnatol (BWA770U) mesylate is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol mesylate shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Crisnatol (1.3 μg/mL; 24-72 h) mesylate 抑制 HepG2 细胞的复制，使细胞活力降低 35%[2]。 Cell Viability Assay[2] Cell Line: HepG2 cells Concentration: 1.3 μg/mL Incubation Time: 24 hours, 48 hours, 72 hours, and 126 hours Result: Inhibited cell viability at 48 hr.
In Vivo	Crisnatol (25 mg/kg; p.o.; single dose) mesylate 显示出口服活性，并通过放射自显影显示大鼠粪便提取物的稳定代谢物谱[2]。
References	[1]. Adams DJ. In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator. Cancer Res. 1989 Dec 1;49(23):6615-20. [2]. Patel DK, et al. Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites. Biochem Pharmacol. 1991 Jul 5;42(2):337-46. [3]. Patel DK, et al. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat. Drug Metab Dispos. 1991 Mar-Apr;19(2):491-7.

Molecular Formula	C₂₄H₂₇NO₅S
Molecular Weight	441.54000
Exact Mass	441.16100
PSA	115.24000
LogP	4.95480

Crisnatol mesilate

CRISNATOL MESYLATE

BW-A770U mesylate

770U82 Mesylate

Crisnatol mesylate

Use of Crisnatol mesylate

Names

Crisnatol mesylate Biological Activity

Chemical & Physical Properties

Synonyms