Crisnatol mesylate

Names

[ Name ]:
Crisnatol mesylate

[Synonym ]:
Crisnatol mesilate
CRISNATOL MESYLATE
BW-A770U mesylate
770U82 Mesylate

Biological Activity

[Description]:

Crisnatol (BWA770U) mesylate is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol mesylate shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[In Vitro]

Crisnatol (1.3 μg/mL; 24-72 h) mesylate 抑制 HepG2 细胞的复制，使细胞活力降低 35%[2]。 Cell Viability Assay[2] Cell Line: HepG2 cells Concentration: 1.3 μg/mL Incubation Time: 24 hours, 48 hours, 72 hours, and 126 hours Result: Inhibited cell viability at 48 hr.

[In Vivo]

Crisnatol (25 mg/kg; p.o.; single dose) mesylate 显示出口服活性，并通过放射自显影显示大鼠粪便提取物的稳定代谢物谱[2]。

[References]

[1]. Adams DJ. In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator. Cancer Res. 1989 Dec 1;49(23):6615-20.

[2]. Patel DK, et al. Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites. Biochem Pharmacol. 1991 Jul 5;42(2):337-46.

[3]. Patel DK, et al. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat. Drug Metab Dispos. 1991 Mar-Apr;19(2):491-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₇NO₅S

[ Molecular Weight ]:
441.54000

[ Exact Mass ]:
441.16100

[ PSA ]:
115.24000

[ LogP ]:
4.95480

Related Compounds

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