96389-69-4

96389-69-4 structure

Name: Crisnatol mesylate
Chemical Name: 2-(chrysen-6-ylmethylamino)-2-methylpropane-1,3-diol,methanesulfonic acid
CAS Number: 96389-69-4
Molecular Formula: C₂₄H₂₇NO₅S
Molecular Weight: 441.54000
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2017-06-15 12:19:36
Modify Date: 2024-01-05 12:35:02
Crisnatol (BWA770U) mesylate is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol mesylate shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts[1][2][3].

Name	2-(chrysen-6-ylmethylamino)-2-methylpropane-1,3-diol,methanesulfonic acid
Synonyms	Crisnatol mesilate CRISNATOL MESYLATE BW-A770U mesylate 770U82 Mesylate

Description	Crisnatol (BWA770U) mesylate is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol mesylate shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Crisnatol (1.3 μg/mL; 24-72 h) mesylate 抑制 HepG2 细胞的复制，使细胞活力降低 35%[2]。 Cell Viability Assay[2] Cell Line: HepG2 cells Concentration: 1.3 μg/mL Incubation Time: 24 hours, 48 hours, 72 hours, and 126 hours Result: Inhibited cell viability at 48 hr.
In Vivo	Crisnatol (25 mg/kg; p.o.; single dose) mesylate 显示出口服活性，并通过放射自显影显示大鼠粪便提取物的稳定代谢物谱[2]。
References	[1]. Adams DJ. In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator. Cancer Res. 1989 Dec 1;49(23):6615-20. [2]. Patel DK, et al. Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites. Biochem Pharmacol. 1991 Jul 5;42(2):337-46. [3]. Patel DK, et al. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat. Drug Metab Dispos. 1991 Mar-Apr;19(2):491-7.