2-Propen-1-one,1-(4-methoxyphenyl)-3-phenyl-

Modify Date: 2025-08-25 12:29:00

2-Propen-1-one,1-(4-methoxyphenyl)-3-phenyl- structure	Common Name	2-Propen-1-one,1-(4-methoxyphenyl)-3-phenyl-
	CAS Number	959-23-9	Molecular Weight	238.28100
	Density	1.114g/cm3	Boiling Point	397.5ºC at 760mmHg
	Molecular Formula	C₁₆H₁₄O₂	Melting Point	101-103 °C(lit.)
	MSDS	N/A	Flash Point	180.5ºC

Use of 2-Propen-1-one,1-(4-methoxyphenyl)-3-phenyl-

4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. 4'-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity[1].

Name	4'-methoxychalcone
Synonym	More Synonyms

Description	4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. 4'-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PARP Research Areas >> Metabolic Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	PPARγ[1]
In Vitro	4'-Methoxychalcone (5 μM; 8 days) markedly increases the mRNA expression of adipogenic genes during adipocyte differentiation, PPARγ, aP2, FAS, adiponectin and GluT 4[1]. 4'-Methoxychalcone (5 μM; 8 days) reduces the upregulated mRNA expression of IL-6, PAI-1, and MCP-1 by TNF-α in preadipocyte 3T3-L1 cells[1]. 4'-Methoxychalcone (5 μM; 0-8 days) causes an increase in PPARγ expression during differentiation, while C/EBPβ protein expression is relatively unaffected[1]. RT-PCR[1] Cell Line: Preadipocyte 3T3-L1 cells Concentration: 5 μM Incubation Time: 0 day; 2 days; 4 days; 6 days; 8 days Result: Increased the mRNA expression of all adipogenic genes, except GluT1 in adipocyte. Western Blot Analysis[1] Cell Line: Preadipocyte 3T3-L1 cells Concentration: 5 μM Incubation Time: 8 days Result: Increased PPARγ expression in adipocyte.
References	[1]. Han Y, et al. Regulatory effects of 4-methoxychalcone on adipocyte differentiation through PPARγ activation and reverse effect on TNF-α in 3T3-L1 cells. Food Chem Toxicol. 2017 Aug;106(Pt A):17-24.

Density	1.114g/cm3
Boiling Point	397.5ºC at 760mmHg
Melting Point	101-103 °C(lit.)
Molecular Formula	C₁₆H₁₄O₂
Molecular Weight	238.28100
Flash Point	180.5ºC
Exact Mass	238.09900
PSA	26.30000
LogP	3.59130
Index of Refraction	1.606

Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	S26-S36
WGK Germany	3
HS Code	2914509090

Precursor 10
CAS#:102-92-1 Ciprofloxacin H... CAS#:100-66-3 Anisole CAS#:100-06-1 Acetanisole CAS#:100-51-6 Benzyl alcohol
CAS#:100-52-7 Benzaldehyde CAS#:768-60-5 4-Ethynylanisole CAS#:100-07-2 p-Anisoyl chloride CAS#:536-74-3 Phenylacetylene
CAS#:621-82-9 Cinnamic acid CAS#:109643-11-0 1-(4-methoxyphe...
DownStream 7
CAS#:4360-47-8 Cinnamonitrile CAS#:100-09-4 p-Anisic acid CAS#:111873-68-8 5-(4-methoxyphe... CAS#:65-85-0 benzoic acid
CAS#:5739-38-8 1-(4-methoxyphe... CAS#:1023-17-2 1-(4-Methoxyphe... CAS#:32664-28-1 1H-Pyrazole,3-(...

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%