SEC inhibitor KL-1
Modify Date: 2025-08-25 20:01:58
SEC inhibitor KL-1 structure
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Common Name | SEC inhibitor KL-1 | ||
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| CAS Number | 900308-84-1 | Molecular Weight | 345.78 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16ClNO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SEC inhibitor KL-1SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM[1]. |
| Name | SEC inhibitor KL-1 |
|---|
| Description | SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM[1]. |
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| Related Catalog | |
| Target |
SEC[1] |
| References |
| Molecular Formula | C18H16ClNO4 |
|---|---|
| Molecular Weight | 345.78 |
| InChIKey | ARTVILCEXNCVIN-UHFFFAOYSA-N |
| SMILES | COc1cccc(C(O)=CC(=O)C(=O)Nc2cc(Cl)ccc2C)c1 |