SEC inhibitor KL-2
Modify Date: 2025-08-25 19:31:10
SEC inhibitor KL-2 structure
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Common Name | SEC inhibitor KL-2 | ||
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| CAS Number | 900308-51-2 | Molecular Weight | 333.74 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H13ClFNO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SEC inhibitor KL-2SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM[1]. |
| Name | SEC inhibitor KL-2 |
|---|
| Description | SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM[1]. |
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| Related Catalog | |
| Target |
SEC[1] |
| References |
| Molecular Formula | C17H13ClFNO3 |
|---|---|
| Molecular Weight | 333.74 |
| InChIKey | FKGPCOZLGSAHRR-UHFFFAOYSA-N |
| SMILES | Cc1ccc(Cl)cc1NC(=O)C(=O)C=C(O)c1ccc(F)cc1 |