1799604-71-9
1799604-71-9 structure
- Name: SHP2 inhibitor 2
- Chemical Name: SHP2 inhibitor 2
- CAS Number: 1799604-71-9
- Molecular Formula: C22H18IN3O6S
- Molecular Weight: 579.365
- Create Date: 2020-01-11 19:19:44
- Modify Date: 2024-01-04 23:47:43
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A nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM; displays 5-fold selectivity over SHP1, and >10-fold secltivity over other PTPs; effectively reduces the EGF-induced ERK1/2 phosphorylation, increased the phosphorylation level of Y118 in paxillin, reduces H1975 cell proliferation in a dose-dependent manner.
| Name | SHP2 inhibitor 2 |
|---|
| Description | A nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM; displays 5-fold selectivity over SHP1, and >10-fold secltivity over other PTPs; effectively reduces the EGF-induced ERK1/2 phosphorylation, increased the phosphorylation level of Y118 in paxillin, reduces H1975 cell proliferation in a dose-dependent manner. |
|---|---|
| References | References 1. He R, et al. ACS Med Chem Lett. 2015 Jun 8;6(7):782-6. View Related Products by Target Protein Phosphatase/PTP |
| Molecular Formula | C22H18IN3O6S |
|---|---|
| Molecular Weight | 579.365 |