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866842-71-9

866842-71-9 structure

866842-71-9 structure

Name: UCK2 Inhibitor-2
Chemical Name: UCK2 Inhibitor-2
CAS Number: 866842-71-9
Molecular Formula: C₂₈H₂₃N₃O₄S
Molecular Weight: 497.56
Catalog: Research Areas Cancer
Create Date: 2023-01-24 11:01:13
Modify Date: 2024-04-03 06:29:21
UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 µM. UCK2 Inhibitor-2 can suppress uridine salvage in cells[1].

Name	UCK2 Inhibitor-2

Description	UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 µM. UCK2 Inhibitor-2 can suppress uridine salvage in cells[1].
Related Catalog	Research Areas >> Cancer
Target	IC50: 3.8 µM (UCK2)[1]
In Vitro	UCK2 Inhibitor-2 (compound 20874830) 在浓度为 50 µM 时对 K562 细胞中的尿苷补救有 52% 的抑制作用。DHODH 的抑制增加了尿苷的回收，而 UCK2 抑制剂 UCK2 Inhibitor-2 (compound 20874830) 可以抑制这种增加[1]。
References	[1]. Ayse Okesli-Armlovich, et al. Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2559-2564.

Molecular Formula	C₂₈H₂₃N₃O₄S
Molecular Weight	497.56

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