Cot inhibitor-2

Modify Date: 2024-02-06 17:10:31

Cot inhibitor-2 structure	Common Name	Cot inhibitor-2
	CAS Number	915363-56-3	Molecular Weight	539.43500
	Density	1.45	Boiling Point	713.3ºC at 760 mmHg
	Molecular Formula	C₂₆H₂₅Cl₂FN₈	Melting Point	N/A
	MSDS	N/A	Flash Point	385.2ºC

Use of Cot inhibitor-2

Cot inhibitor-2 is a COT/Tpl2 inhibitor.

Name	8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethylpiperidin-4-yl)triazol-4-yl]methylamino]quinoline-3-carbonitrile
Synonym	More Synonyms

Description	Cot inhibitor-2 is a COT/Tpl2 inhibitor.
Related Catalog	Signaling Pathways >> Apoptosis >> TNF Receptor Research Areas >> Cancer
References	[1]. Wu, Junjun et al Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-production in human whole blood. Bioorganic & Medicinal Chemistry Letters (2009), 19(13), 3485-3488.

Density	1.45
Boiling Point	713.3ºC at 760 mmHg
Molecular Formula	C₂₆H₂₅Cl₂FN₈
Molecular Weight	539.43500
Flash Point	385.2ºC
Exact Mass	538.15600
PSA	94.69000
LogP	6.24028
Index of Refraction	1.702

6-amino-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile structure

6-amino-8-chlor...

CAS#:915364-18-0

1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazole-4-carbaldehyde structure

1-(1-ethylpiper...

CAS#:1175146-85-6

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Cot inhibitor-2 Structure

Cot inhibitor-2

CAS#:915363-56-3

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 13 p. 3485 - 3488

6-amino-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile structure

6-amino-8-chlor...

CAS#:915364-18-0

1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazole-4-carbaldehyde structure

1-(1-ethylpiper...

CAS#:1175146-85-6

~%

Cot inhibitor-2 Structure

Cot inhibitor-2

CAS#:915363-56-3

Literature: Wu, Junjun; Green, Neal; Hotchandani, Rajeev; Hu, Yonghan; Condon, Jeffrey; Huang, Adrian; Kaila, Neelu; Li, Huan-Qiu; Guler, Satenig; Li, Wei; Tam, Steve Y.; Wang, Qin; Pelker, Jeffrey; Marusic, Suzana; Hsu, Sang; Perry Hall; Telliez, Jean-Baptiste; Cui, Junqing; Lin, Lih-Ling Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 13 p. 3485 - 3488

Precursor 2
CAS#:915364-18-0 6-amino-8-chlor... CAS#:1175146-85-6 1-(1-ethylpiper...
DownStream 0

substituted 6-aminoquinoline-3-carbonitrile,34

8-CHLORO-4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-[[[1-(1-ETHYLPIPERIDIN-4-YL)-1H-1,2,3-TRIAZOL-4-YL]METHYL]AMINO]QUINOLINE-3-CARBONITRILE

Cot inhibitor-2

DC Chemicals Limited
China
Product Name: Cot inhibitor-2
Price: $500.0/100mg $1000.0/250mg $2000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: WYETH-TPL-2 KINASE INHIBITOR-2
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $328/10mM*1mLinDMSO

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