ML-SI3

Modify Date: 2024-01-11 22:08:08

ML-SI3 structure	Common Name	ML-SI3
	CAS Number	891016-02-7	Molecular Weight	429.576
	Density	1.3±0.1 g/cm3	Boiling Point	589.3±60.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₃₁N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	310.2±32.9 °C

Use of ML-SI3

ML-SI3 is a TRPML Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC50s of 4.7 µM and 1.7 µM respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy[1][5].

Name	N-{2-[4-(2-Methoxyphenyl)-1-piperazinyl]cyclohexyl}benzenesulfonamide
Synonym	More Synonyms

Description	ML-SI3 is a TRPML Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC50s of 4.7 µM and 1.7 µM respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy[1][5].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease
Target	TRPML1:4.7 μM (IC50) TRPML2:1.7 μM (IC50) TRPML3:12.5 μM (IC50)
In Vitro	ML-SI3 (10 μM) inhibits ML-SA1-evoked Ca2+ signals in HeLa cells[2]. ML-SI3 (25-75 μM, 24h) disrupts tegumental integrity of adult schistosomes[3]. ML-SI3 (10 μM) blocks Rapamycin (HY-10219)-evoked ITRPML1 in mimic of lysosomal lumen[4]. ML-SI3 (3 µM, 6 h) abolishes the increase in both LC3II and p62 levels induced by hypoxia/reoxygenation (H/R) (4 h H/2 h R) in neonatal rat ventricular myocytes (NRVM)[5].
In Vivo	ML-SI3 (1.5 mg/kg, i.p., four times) attenuates I/R injury in mouse cardiomyocytes[5]. Animal Model: Myocardial Ischemia/reperfusion (I/R) injury mice[5] Dosage: 1.5 mg/kg Administration: Intraperitoneal injection (i.p.), four times before and during the in vivo I/R (ischemia 30 min and reperfusion 1 day) Result: Restored the blocked autophagic fux in the cardiomyocytes subjected to I/R.

Density	1.3±0.1 g/cm3
Boiling Point	589.3±60.0 °C at 760 mmHg
Molecular Formula	C₂₃H₃₁N₃O₃S
Molecular Weight	429.576
Flash Point	310.2±32.9 °C
Exact Mass	429.208618
LogP	4.00
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.629
Storage condition	-20°C

Hazard Codes	Xi

MFCD14811190

N-{2-[4-(2-Methoxyphenyl)-1-piperazinyl]cyclohexyl}benzenesulfonamide

Benzenesulfonamide, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]cyclohexyl]-

ML-SI3

DC Chemicals Limited
China
Product Name: ML-SI3
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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ML-SI3

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