1883548-87-5

1883548-87-5 structure

Name: ML 179
Chemical Name: ML-179
CAS Number: 1883548-87-5
Molecular Formula: C₂₁H₂₅F₃N₄O₂
Molecular Weight: 422.44
Catalog: Research Areas Cancer
Create Date: 2021-05-10 16:57:30
Modify Date: 2025-08-26 17:49:41
ML179 (SR-1309) is a inverse LRH1 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer[1].

Name	ML-179
Synonyms	2,4(1H,3H)-Pyrimidinedione, 3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]- 3-Cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]-1-piperazinyl}-2,4(1H,3H)-pyrimidinedione 3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-1H-pyrimidine-2,4-dione ML-179

Description	ML179 (SR-1309) is a inverse LRH1 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	LRH-1[1]
References	[1]. Busby S, et al. Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2). 2010 Oct 12 [updated 2011 Dec 12].