Z-Pro-prolinal
Z-Pro-prolinal structure
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Common Name | Z-Pro-prolinal | ||
|---|---|---|---|---|
| CAS Number | 88795-32-8 | Molecular Weight | 330.37800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H22N2O4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Z-Pro-prolinalZ-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP[1][2][3]. |
| Name | N-Benzyloxycarbonylprolylprolinal |
|---|---|
| Synonym | More Synonyms |
| Description | Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.4 nM (porcine PREP)[2] Ki: 3.7 nM (PREP from bovine brain)[1] |
| In Vivo | Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) (100 mg/kg; p.o.; once) increases septal vasopressin content in rats[3]. Animal Model: Male Wistar rats[3] Dosage: 100 mg/kg Administration: Oral administration, once Result: Significantly increased the septal arginine-vasopressin (AVP) content. |
| Molecular Formula | C18H22N2O4 |
|---|---|
| Molecular Weight | 330.37800 |
| Exact Mass | 330.15800 |
| PSA | 66.92000 |
| LogP | 1.85330 |
| InChIKey | ORZXYSPOAVJYRU-HOTGVXAUSA-N |
| SMILES | O=CC1CCCN1C(=O)C1CCCN1C(=O)OCc1ccccc1 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
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Recombinant prolylcarboxypeptidase activates plasma prekallikrein.
Blood 103(12) , 4554-61, (2004) The serine protease prolylcarboxypeptidase (PRCP), isolated from human umbilical vein endothelial cells (HUVECs), is a plasma prekallikrein (PK) activator. PRCP cDNA was cloned in pMT/BIP/V5-HIS-C, tr... |
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Enzymatic processing of angiotensin peptides by human glomerular endothelial cells.
Am. J. Physiol. Renal Physiol. 302(12) , F1583-94, (2012) The intraglomerular renin-angiotensin system (RAS) is linked to the pathogenesis of progressive glomerular diseases. Glomerular podocytes and mesangial cells play distinct roles in the metabolism of a... |
| N-benzyloxycarbonyl-L-prolyl-L-prolinal |
| N-benzyloxycarbonyl-S-prolyl-S-prolinal |
| Z-pro-prolinal |
| Z-Pro-prolinal |