Prolyl Endopeptidase Inhibitor 1

Modify Date: 2024-01-09 14:48:41

Prolyl Endopeptidase Inhibitor 1 Structure
Prolyl Endopeptidase Inhibitor 1 structure
Common Name Prolyl Endopeptidase Inhibitor 1
CAS Number 86925-97-5 Molecular Weight 330.37800
Density 1.231g/cm3 Boiling Point 448.6ºC at 760 mmHg
Molecular Formula C15H24N2O4 Melting Point N/A
MSDS Chinese Flash Point 225.1ºC

 Use of Prolyl Endopeptidase Inhibitor 1


Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent prolyl endopeptidase (PEP; PE) inhibitor, with a Ki value of 15 nM. Prolyl Endopeptidase Inhibitor 1 has anti-amnesic effect[1].

 Names

Name prolyl endopeptidase inhibitor ii
Synonym More Synonyms

 Prolyl Endopeptidase Inhibitor 1 Biological Activity

Description Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent prolyl endopeptidase (PEP; PE) inhibitor, with a Ki value of 15 nM. Prolyl Endopeptidase Inhibitor 1 has anti-amnesic effect[1].
Related Catalog
Target

Ki: 15 nM (prolyl endopeptidase)[1]

In Vitro Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) strongly inhibits the mammalian prolyl endopeptidase with a Ki value of nM order, while the Ki value for the microbial enzyme is only of microM order (Ki=3.2 μM for Flavobacterium)[1].
References

[1]. Yoshimoto T, et al. Specific inhibitors for prolyl endopeptidase and their anti-amnesic effect. J Pharmacobiodyn. 1987 Dec;10(12):730-5.

[2]. Yoshimoto T, et al. Comparison of inhibitory effects of prolinal-containing peptide derivatives on prolyl endopeptidases from bovine brain and Flavobacterium. J Biochem. 1985 Oct;98(4):975-9.

 Chemical & Physical Properties

Density 1.231g/cm3
Boiling Point 448.6ºC at 760 mmHg
Molecular Formula C15H24N2O4
Molecular Weight 330.37800
Flash Point 225.1ºC
Exact Mass 330.15800
PSA 66.92000
LogP 1.85330
Index of Refraction 1.561

 Synonyms

Z-PRO-PRO-CHO
Z-Pro-prolinal
N-benzyloxycarbonylprolylprolinal
Z-PROLYL-PROLINAL
Z-PP-CHO
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