2205125-60-4

2205125-60-4 structure

Name: Prolyl Hydroxylase inhibitor 1
Chemical Name: Prolyl Hydroxylase inhibitor 1
CAS Number: 2205125-60-4
Molecular Formula: C₁₉H₁₈ClN₅O₄
Molecular Weight: 415.83
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
Create Date: 2019-06-01 18:34:27
Modify Date: 2025-08-25 20:54:04
Prolyl Hydroxylase inhibitor 1 (Compound 15i) is an orally active hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor with an IC50 of 62.23 nM[1]. Antianemia agent[1].

Name	Prolyl Hydroxylase inhibitor 1

Description	Prolyl Hydroxylase inhibitor 1 (Compound 15i) is an orally active hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor with an IC50 of 62.23 nM[1]. Antianemia agent[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: 62.23±2.33nM (HIF-PHD)[1]
References	[1]. Wu Y, et al. Click Chemistry-Based Discovery of [3-Hydroxy-5-(1 H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia-Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia. J Med Chem. 2018 Jun 28;61(12):5332-5349.

Molecular Formula	C₁₉H₁₈ClN₅O₄
Molecular Weight	415.83