Prolyl Endopeptidase Inhibitor 1

Names

[ Name ]:
Prolyl Endopeptidase Inhibitor 1

[Synonym ]:
Z-PRO-PRO-CHO
Z-Pro-prolinal
N-benzyloxycarbonylprolylprolinal
Z-PROLYL-PROLINAL
Z-PP-CHO

Biological Activity

[Description]:

Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent prolyl endopeptidase (PEP; PE) inhibitor, with a Ki value of 15 nM. Prolyl Endopeptidase Inhibitor 1 has anti-amnesic effect[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

Ki: 15 nM (prolyl endopeptidase)[1]

[In Vitro]

Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) strongly inhibits the mammalian prolyl endopeptidase with a Ki value of nM order, while the Ki value for the microbial enzyme is only of microM order (Ki=3.2 μM for Flavobacterium)[1].

[References]

[1]. Yoshimoto T, et al. Specific inhibitors for prolyl endopeptidase and their anti-amnesic effect. J Pharmacobiodyn. 1987 Dec;10(12):730-5.

[2]. Yoshimoto T, et al. Comparison of inhibitory effects of prolinal-containing peptide derivatives on prolyl endopeptidases from bovine brain and Flavobacterium. J Biochem. 1985 Oct;98(4):975-9.

Chemical & Physical Properties

[ Density]:
1.231g/cm3

[ Boiling Point ]:
448.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₄N₂O₄

[ Molecular Weight ]:
330.37800

[ Flash Point ]:
225.1ºC

[ Exact Mass ]:
330.15800

[ PSA ]:
66.92000

[ LogP ]:
1.85330

[ Index of Refraction ]:
1.561

Related Compounds

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