86925-97-5

86925-97-5 structure

Name: Prolyl Endopeptidase Inhibitor 1
Chemical Name: prolyl endopeptidase inhibitor ii
CAS Number: 86925-97-5
Molecular Formula: C₁₅H₂₄N₂O₄
Molecular Weight: 330.37800
Catalog: Research Areas Neurological Disease
Create Date: 2017-07-01 09:21:17
Modify Date: 2024-01-09 14:48:41
Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent prolyl endopeptidase (PEP; PE) inhibitor, with a Ki value of 15 nM. Prolyl Endopeptidase Inhibitor 1 has anti-amnesic effect[1].

Name	prolyl endopeptidase inhibitor ii
Synonyms	Z-PRO-PRO-CHO Z-Pro-prolinal N-benzyloxycarbonylprolylprolinal Z-PROLYL-PROLINAL Z-PP-CHO

Description	Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent prolyl endopeptidase (PEP; PE) inhibitor, with a Ki value of 15 nM. Prolyl Endopeptidase Inhibitor 1 has anti-amnesic effect[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Ki: 15 nM (prolyl endopeptidase)[1]
In Vitro	Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) strongly inhibits the mammalian prolyl endopeptidase with a Ki value of nM order, while the Ki value for the microbial enzyme is only of microM order (Ki=3.2 μM for Flavobacterium)[1].
References	[1]. Yoshimoto T, et al. Specific inhibitors for prolyl endopeptidase and their anti-amnesic effect. J Pharmacobiodyn. 1987 Dec;10(12):730-5. [2]. Yoshimoto T, et al. Comparison of inhibitory effects of prolinal-containing peptide derivatives on prolyl endopeptidases from bovine brain and Flavobacterium. J Biochem. 1985 Oct;98(4):975-9.