Z-Pro-prolinal

Names

[ Name ]:
Z-Pro-prolinal

[Synonym ]:
N-benzyloxycarbonyl-L-prolyl-L-prolinal
N-benzyloxycarbonyl-S-prolyl-S-prolinal
Z-pro-prolinal
Z-Pro-prolinal

Biological Activity

[Description]:

Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP[1][2][3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[Target]

IC50: 0.4 nM (porcine PREP)[2] Ki: 3.7 nM (PREP from bovine brain)[1]

[In Vivo]

Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) (100 mg/kg; p.o.; once) increases septal vasopressin content in rats[3]. Animal Model: Male Wistar rats[3] Dosage: 100 mg/kg Administration: Oral administration, once Result: Significantly increased the septal arginine-vasopressin (AVP) content.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₂N₂O₄

[ Molecular Weight ]:
330.37800

[ Exact Mass ]:
330.15800

[ PSA ]:
66.92000

[ LogP ]:
1.85330

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Articles

Recombinant prolylcarboxypeptidase activates plasma prekallikrein.

Blood 103(12) , 4554-61, (2004)

The serine protease prolylcarboxypeptidase (PRCP), isolated from human umbilical vein endothelial cells (HUVECs), is a plasma prekallikrein (PK) activator. PRCP cDNA was cloned in pMT/BIP/V5-HIS-C, tr...

Enzymatic processing of angiotensin peptides by human glomerular endothelial cells.

Am. J. Physiol. Renal Physiol. 302(12) , F1583-94, (2012)

The intraglomerular renin-angiotensin system (RAS) is linked to the pathogenesis of progressive glomerular diseases. Glomerular podocytes and mesangial cells play distinct roles in the metabolism of a...

Related Compounds

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