88795-32-8
88795-32-8 structure
- Name: Z-Pro-prolinal
- Chemical Name: N-Benzyloxycarbonylprolylprolinal
- CAS Number: 88795-32-8
- Molecular Formula: C18H22N2O4
- Molecular Weight: 330.37800
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-04-23 21:18:23
- Modify Date: 2024-01-09 18:51:26
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Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP[1][2][3].
| Name | N-Benzyloxycarbonylprolylprolinal |
|---|---|
| Synonyms |
N-benzyloxycarbonyl-L-prolyl-L-prolinal
N-benzyloxycarbonyl-S-prolyl-S-prolinal Z-pro-prolinal Z-Pro-prolinal |
| Description | Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.4 nM (porcine PREP)[2] Ki: 3.7 nM (PREP from bovine brain)[1] |
| In Vivo | Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) (100 mg/kg; p.o.; once) increases septal vasopressin content in rats[3]. Animal Model: Male Wistar rats[3] Dosage: 100 mg/kg Administration: Oral administration, once Result: Significantly increased the septal arginine-vasopressin (AVP) content. |
| Molecular Formula | C18H22N2O4 |
|---|---|
| Molecular Weight | 330.37800 |
| Exact Mass | 330.15800 |
| PSA | 66.92000 |
| LogP | 1.85330 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |