Naloxonazine dihydrochloride

Modify Date: 2024-04-01 18:49:59

Naloxonazine dihydrochloride structure	Common Name	Naloxonazine dihydrochloride
	CAS Number	880759-65-9	Molecular Weight	687.22400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₈H₄₃ClN₄O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Naloxonazine dihydrochloride

Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity[1][2][3].

Name	Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, [(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazone, dihydrochloride, (5α)
Synonym	More Synonyms

Description	Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	μ-opioid receptor:5.4 nM (IC50)
In Vitro	Naloxonazine is relatively stable in solution[2]. Naloxonazine (72 h) is active against the intracellular amastigote stage of Leishmania donovani with a half maximal inhibitory concentration (GI50) of 3.45 μM[3]. Naloxonazine (10 μM; 0-72 h) is active at early stages of Leishmania donovani infection[3]. Naloxonazine affects acidic compartments of the host cell which in turn limit L. donovani intracellular growth[3].
In Vivo	Naloxonazine (20 mg/kg; i.p.; once) attenuates the increment of locomotor activity induced by acute methamphetamine in mice[1] Animal Model: Male ICR mice, methamphetamine (METH)-induced locomotor activity model[1] Dosage: 20 mg/kg Administration: Intraperitoneal injection, once, 60 min before injecting saline (i.p.) or METH (1 mg/kg, i.p.) Result: Significantly attenuated the acute METH-induced increase in locomotor activity and phosphor-Thr75 DARPP-32 levels.
References	[1]. Chien CC, et al. Naloxonazine, a specific mu-opioid receptor antagonist, attenuates the increment of locomotor activity induced by acute methamphetamine in mice. Toxicol Lett. 2012 Jul 7;212(1):61-5. [2]. Hahn EF, et al. Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites. Life Sci. 1982 Sep 20-27;31(12-13):1385-8. [3]. De Muylder G, et al. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec 30;10(12):e0005234.

Molecular Formula	C₃₈H₄₃ClN₄O₆
Molecular Weight	687.22400
Exact Mass	686.28700
PSA	130.58000
LogP	3.95300

NALOXONAZINE DIHYDROCHLORIDE HYDRATE

NALOXONAZINE DIHYDROCHLORIDE OPIOID ANTA GONIST

Naloxonazine dihydrochloride

Demethylasterriquinone B1

DC Chemicals Limited
China
Product Name: Naloxonazine Dihydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: bis[(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazone hydrate dihydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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