82824-01-9

82824-01-9 structure

Name: Naloxonazine dihydrochloride
Chemical Name: Naloxonazine dihydrochloride,Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene]hydrazinedihydrochloride
CAS Number: 82824-01-9
Molecular Formula: C₃₈H₄₂N₄O₆
Molecular Weight: 650.76300
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2018-09-11 19:47:28
Modify Date: 2024-01-03 02:12:09
Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function[1].

Name	Naloxonazine dihydrochloride,Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene]hydrazinedihydrochloride
Synonyms	NALOXONAZINE DIHYDROCHLORIDE OPIOID ANTA GONIST NALOXONAZINE DIHYDROCHLORIDE NALOXONAZINE 2HCL naloxonazine

Description	Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
In Vitro	Naloxonazine(0-50 μM, 24-72 h) 对细胞内 Leishmania donovani 的无鞭毛体阶段具有抑制活性，其最大抑制浓度 GI50为3.45 μM。而对 THP-1 宿主细胞的 GI50为 34 μM[1]。 Naloxonazine(10 μM, 4-72 h)可以抑制寄生虫细胞内生长，处理 24 h 可以抑制 70%，处理 72 h可以抑制 95%[1]。 Naloxonazine(10 μM, 4 or 24-72 h)导致 vATPase亚基 (ATP6V0C和TCIRG1) 和肌动蛋白 (ACTB) 基因及蛋白表达水平上调，并且影响了宿主细胞的细胞内酸性区室[1]。
In Vivo	Naloxonazine (0-15 mg/kg, i.p., 20 h)在雄性 Wistar大鼠中，当剂量为 15 mg/kg 时，(olfactory discriminative stimulus)S+/CS+ 相关反应显著降低约 55%，由 14.63 降至 6.82。而在(olfactory stimulus)S-/CS-刺激条件下观察到更大的行为抑制，反应率降低 66%，从 9.00 降至 3.00[2]。
References	[1]. Géraldine De Muylder, et al. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec 30;10(12):e0005234. [2]. Roberto Ciccocioppo, et al. Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats. Neuropsychopharmacology. 2002 Sep;27(3):391-9.

Density	1.12g/cm3
Boiling Point	433.7ºC at 760 mmHg
Molecular Formula	C₃₈H₄₂N₄O₆
Molecular Weight	650.76300
Flash Point	216.1ºC
Exact Mass	650.31000
PSA	130.58000
LogP	3.15100
Index of Refraction	1.612

WGK Germany	3

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