Raclopride
Modify Date: 2024-01-04 21:58:08
Raclopride structure
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Common Name | Raclopride | ||
|---|---|---|---|---|
| CAS Number | 84225-95-6 | Molecular Weight | 347.24 | |
| Density | 1.288g/cm3 | Boiling Point | 420.3ºC at 760 mmHg | |
| Molecular Formula | C15H20Cl2N2O3 | Melting Point | 54 °C | |
| MSDS | N/A | Flash Point | 208ºC | |
Use of RacloprideRaclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively[1]. |
| Name | 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide |
|---|---|
| Synonym | More Synonyms |
| Description | Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 1.8 nM (D2 receptor), 3.5 nM (D3 receptor), 2400 nM (D4 receptor), 18000 nM (D1 receptor)[1] |
| References |
[1]. Seeman P, et al. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15(7):264-70. |
| Density | 1.288g/cm3 |
|---|---|
| Boiling Point | 420.3ºC at 760 mmHg |
| Melting Point | 54 °C |
| Molecular Formula | C15H20Cl2N2O3 |
| Molecular Weight | 347.24 |
| Flash Point | 208ºC |
| Exact Mass | 346.08500 |
| PSA | 61.80000 |
| LogP | 3.25050 |
| Index of Refraction | 1.563 |
| Safety Phrases | 22-24/25 |
|---|
|
~64%
Raclopride CAS#:84225-95-6 |
| Literature: AARHUS UNIVERSITET; SKRYDSTRUP, Troels; LINDHARDT, Anders Thyboe; HERMANGE, Philippe; TAANING, Rolf Hejle; FRIIS, Stig Duering Patent: WO2012/79583 A1, 2012 ; Location in patent: Page/Page column 95; 96 ; |
|
~71%
Raclopride CAS#:84225-95-6 |
| Literature: Fei, Xiangshu; Mock, Bruce H.; DeGrado, Timothy R.; Wang, Ji-Quari; Glick-Wilson, Barbara E.; Sullivan, Michael L.; Hutchins, Gary D.; Zheng, Qi-Huang Synthetic Communications, 2004 , vol. 34, # 10 p. 1897 - 1907 |
|
~5%
Raclopride CAS#:84225-95-6 |
| Literature: Haroun, Samar; Sanei, Zahra; Jivan, Salma; Schaffer, Paul; Ruth, Thomas J.; Li, Paul C.H. Canadian Journal of Chemistry, 2013 , vol. 91, # 5 p. 326 - 332 |
|
~%
Raclopride CAS#:84225-95-6 |
| Literature: Synthetic Communications, , vol. 34, # 10 p. 1897 - 1907 |
|
~%
Raclopride CAS#:84225-95-6 |
| Literature: Synthetic Communications, , vol. 34, # 10 p. 1897 - 1907 |
![(S)-(-)-3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,6-dimethoxybenzamide structure](https://www.chemsrc.com/caspic/327/84225-94-5.png)
![(S)-3,5-DICHLORO-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2,6-DIHYDROXY-BENZAMIDE structure](https://www.chemsrc.com/caspic/150/119670-11-0.png)
| des-His1-[Glu9]-Glucagon (1-29) amide |
| FLA 870 |
| PRASEODYMIUM(III) TRIFLUOROMETHANESULFONATE |
| 3,5-DICHLORO-N-[[(2S)-1-ETHYL-2-PYRROLIDINYL]METHYL]-2-HYDROXY-6-METHOXYBENZAMIDE |
| (S)-3,5-Dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide |
| 3,5-DICHLORO-N-(((2S)-1-ETHYL-2-PYRROLIDINYL)METHYL)-2-HYDROXY-6-METHOXYBENZAMIDE |
| S(-)-Raclopride L-Tartrate |
| RACLOPRIDE |
| raclopride |
| (S)-(-)-RACLOPRIDE |