84225-95-6

84225-95-6 structure

Name: Raclopride
Chemical Name: 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
CAS Number: 84225-95-6
Molecular Formula: C₁₅H₂₀Cl₂N₂O₃
Molecular Weight: 347.24
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-04-04 08:00:00
Modify Date: 2025-08-25 10:06:21
Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively[1].

Name	3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
Synonyms	des-His1-[Glu9]-Glucagon (1-29) amide FLA 870 PRASEODYMIUM(III) TRIFLUOROMETHANESULFONATE 3,5-DICHLORO-N-[[(2S)-1-ETHYL-2-PYRROLIDINYL]METHYL]-2-HYDROXY-6-METHOXYBENZAMIDE (S)-3,5-Dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide 3,5-DICHLORO-N-(((2S)-1-ETHYL-2-PYRROLIDINYL)METHYL)-2-HYDROXY-6-METHOXYBENZAMIDE S(-)-Raclopride L-Tartrate RACLOPRIDE raclopride (S)-(-)-RACLOPRIDE

Description	Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	Ki: 1.8 nM (D2 receptor), 3.5 nM (D3 receptor), 2400 nM (D4 receptor), 18000 nM (D1 receptor)[1]
References	[1]. Seeman P, et al. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15(7):264-70.

Density	1.288g/cm3
Boiling Point	420.3ºC at 760 mmHg
Melting Point	54 °C
Molecular Formula	C₁₅H₂₀Cl₂N₂O₃
Molecular Weight	347.24
Flash Point	208ºC
Exact Mass	346.08500
PSA	61.80000
LogP	3.25050
Index of Refraction	1.563

Safety Phrases	22-24/25

1382903-07-2

22795-99-9

13939-06-5

~64%

84225-95-6

Literature: AARHUS UNIVERSITET; SKRYDSTRUP, Troels; LINDHARDT, Anders Thyboe; HERMANGE, Philippe; TAANING, Rolf Hejle; FRIIS, Stig Duering Patent: WO2012/79583 A1, 2012 ; Location in patent: Page/Page column 95; 96 ;

84225-94-5

~71%

84225-95-6

Literature: Fei, Xiangshu; Mock, Bruce H.; DeGrado, Timothy R.; Wang, Ji-Quari; Glick-Wilson, Barbara E.; Sullivan, Michael L.; Hutchins, Gary D.; Zheng, Qi-Huang Synthetic Communications, 2004 , vol. 34, # 10 p. 1897 - 1907

119670-11-0

74-88-4

~5%

84225-95-6

Literature: Haroun, Samar; Sanei, Zahra; Jivan, Salma; Schaffer, Paul; Ruth, Thomas J.; Li, Paul C.H. Canadian Journal of Chemistry, 2013 , vol. 91, # 5 p. 326 - 332

73219-91-7

84225-95-6

Literature: Synthetic Communications, , vol. 34, # 10 p. 1897 - 1907

32541-62-1

84225-95-6

Literature: Synthetic Communications, , vol. 34, # 10 p. 1897 - 1907

Precursor 7
22795-99-9 13939-06-5 84225-94-5 119670-11-0
74-88-4 73219-91-7 32541-62-1
DownStream 1
119670-11-0

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