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Raclopride

Names

[ CAS No. ]:
84225-95-6

[ Name ]:
Raclopride

[Synonym ]:
des-His1-[Glu9]-Glucagon (1-29) amide
FLA 870
PRASEODYMIUM(III) TRIFLUOROMETHANESULFONATE
3,5-DICHLORO-N-[[(2S)-1-ETHYL-2-PYRROLIDINYL]METHYL]-2-HYDROXY-6-METHOXYBENZAMIDE
(S)-3,5-Dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide
3,5-DICHLORO-N-(((2S)-1-ETHYL-2-PYRROLIDINYL)METHYL)-2-HYDROXY-6-METHOXYBENZAMIDE
S(-)-Raclopride L-Tartrate
RACLOPRIDE
raclopride
(S)-(-)-RACLOPRIDE

Biological Activity

[Description]:

Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[Target]

Ki: 1.8 nM (D2 receptor), 3.5 nM (D3 receptor), 2400 nM (D4 receptor), 18000 nM (D1 receptor)[1]


[References]

[1]. Seeman P, et al. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15(7):264-70.

Chemical & Physical Properties

[ Density]:
1.288g/cm3

[ Boiling Point ]:
420.3ºC at 760 mmHg

[ Melting Point ]:
54 °C

[ Molecular Formula ]:
C15H20Cl2N2O3

[ Molecular Weight ]:
347.24

[ Flash Point ]:
208ºC

[ Exact Mass ]:
346.08500

[ PSA ]:
61.80000

[ LogP ]:
3.25050

[ Index of Refraction ]:
1.563

MSDS

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Safety Information

[ Safety Phrases ]:
22-24/25

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds