Aeide-C1-NHS ester

Modify Date: 2024-01-03 15:21:06

Aeide-C1-NHS ester Structure
Aeide-C1-NHS ester structure
Common Name Aeide-C1-NHS ester
CAS Number 824426-32-6 Molecular Weight 198.13600
Density N/A Boiling Point N/A
Molecular Formula C6H6N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Aeide-C1-NHS ester


Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name (2,5-dioxopyrrolidin-1-yl) 2-azidoacetate
Synonym More Synonyms

 Aeide-C1-NHS ester Biological Activity

Description Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C6H6N4O4
Molecular Weight 198.13600
Exact Mass 198.03900
PSA 113.43000
Storage condition 2-8°C

 Synonyms

2,5-Pyrrolidinedione,1-[(azidoacetyl)oxy]
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