824426-32-6

824426-32-6 structure

Name: Aeide-C1-NHS ester
Chemical Name: (2,5-dioxopyrrolidin-1-yl) 2-azidoacetate
CAS Number: 824426-32-6
Molecular Formula: C₆H₆N₄O₄
Molecular Weight: 198.13600
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-06-23 19:16:15
Modify Date: 2024-01-03 15:21:06
Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	(2,5-dioxopyrrolidin-1-yl) 2-azidoacetate
Synonyms	2,5-Pyrrolidinedione,1-[(azidoacetyl)oxy]

Description	Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562