(D-Ala4)-Substance P (4-11)

Modify Date: 2024-01-10 19:40:54

(D-Ala4)-Substance P (4-11) structure	Common Name	(D-Ala4)-Substance P (4-11)
	CAS Number	81381-50-2	Molecular Weight	940.120
	Density	1.3±0.1 g/cm3	Boiling Point	1450.5±65.0 °C at 760 mmHg
	Molecular Formula	C₄₄H₆₅N₁₁O₁₀S	Melting Point	N/A
	MSDS	N/A	Flash Point	831.0±34.3 °C

Use of (D-Ala4)-Substance P (4-11)

[DAla4] Substance P (4-11) is an analog of Substance P (Substance P (HY-P0201)) that inhibits the binding of 125I-Bolton Hunter-conjugated Eledoisin (Eledoisin (HY-P0006)) (IC50 of 0.5 μM) and 125I-Bolton Hunter-conjugated Substance P (IC50 of 0.15 μM) to rat brain cortex membranes[1].

Name	[D-Ala4]-Substance P (4-11)
Synonym	More Synonyms

Description	[DAla4] Substance P (4-11) is an analog of Substance P (Substance P (HY-P0201)) that inhibits the binding of 125I-Bolton Hunter-conjugated Eledoisin (Eledoisin (HY-P0006)) (IC50 of 0.5 μM) and 125I-Bolton Hunter-conjugated Substance P (IC50 of 0.15 μM) to rat brain cortex membranes[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
In Vitro	Eledoisin 和 Substance P 是速激肽的一类肽成员，它们具有相似的生物活性谱。[DAla4] Substance P (4-11) ([D-Ala0-(5-11)]SP) 抑制 125I-Bolton Hunter-conjugated 偶联的 Eledoisin 和 125I-Bolton Hunter 偶联的 Substance P 与大鼠大脑皮层膜的结合[1]。
References	[1]. M A Cascieri, et al. Demonstration of two distinct tachykinin receptors in rat brain cortex. J Biol Chem. 1985 Feb 10;260(3):1501-7.

Density	1.3±0.1 g/cm3
Boiling Point	1450.5±65.0 °C at 760 mmHg
Molecular Formula	C₄₄H₆₅N₁₁O₁₀S
Molecular Weight	940.120
Flash Point	831.0±34.3 °C
Exact Mass	939.463684
PSA	384.29000
LogP	0.37
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.578