(D-Ala4)-Substance P (4-11)

Names

[ Name ]:
(D-Ala4)-Substance P (4-11)

[Synonym ]:
D-Alanyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide
Substance P,fragment 4-11,(D-Ala4)
D-ALA-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
H-D-ALA-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
L-Methioninamide, D-alanyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-
SUBSTANCE P OCTAPEPTIDE D-ALA-4-FRAGMENT 4-11)
(D-ALA4)-SUBSTANCE P (4-11)

Biological Activity

[Description]:

[DAla4] Substance P (4-11) is an analog of Substance P (Substance P (HY-P0201)) that inhibits the binding of 125I-Bolton Hunter-conjugated Eledoisin (Eledoisin (HY-P0006)) (IC50 of 0.5 μM) and 125I-Bolton Hunter-conjugated Substance P (IC50 of 0.15 μM) to rat brain cortex membranes[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[In Vitro]

Eledoisin 和 Substance P 是速激肽的一类肽成员，它们具有相似的生物活性谱。[DAla4] Substance P (4-11) ([D-Ala0-(5-11)]SP) 抑制 125I-Bolton Hunter-conjugated 偶联的 Eledoisin 和 125I-Bolton Hunter 偶联的 Substance P 与大鼠大脑皮层膜的结合[1]。

[References]

[1]. M A Cascieri, et al. Demonstration of two distinct tachykinin receptors in rat brain cortex. J Biol Chem. 1985 Feb 10;260(3):1501-7.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1450.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₄H₆₅N₁₁O₁₀S

[ Molecular Weight ]:
940.120

[ Flash Point ]:
831.0±34.3 °C

[ Exact Mass ]:
939.463684

[ PSA ]:
384.29000

[ LogP ]:
0.37

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.578

Related Compounds

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