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Substance P (4-11)

Names

[ CAS No. ]:
53749-60-3

[ Name ]:
Substance P (4-11)

[Synonym ]:
PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
SUBSTANCE P (4-11)
L-Pro-L-Glu(NH2)-L-Glu(NH2)-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
substance P fragment 4-11 acetate
Substance P,fragment 4-11
OCTA-SUBSTANCE P
SUBSTANCE P(4-11),[D-PRO4,D-TRP7,9]
Substance-P-(4-11)Octa-Substance P
L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
H-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2

Biological Activity

[Description]:

Substance P (4-11), the C-terminus fragment of Substance P (Substance P (HY-P0201)), is a Substance P agonist that shows highly selective for NK1 receptors[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[In Vitro]

Substance P (4-11) 在浓度为 1 nM-100 nM 时显着刺激体外人 T 淋巴细胞的增殖，通过胸苷和亮氨酸的摄取评估[1]。 Substance P (4-11) 在人多形核白细胞 (PMN) 中引发强烈的学发光，具有时间和剂量反应曲线[3]。

[References]

[1]. D G Payan, et al. Specific stimulation of human T lymphocytes by substance P. J Immunol. 1983 Oct;131(4):1613-5.  

[2]. L Wang, et al. Substance P induces ion secretion in mouse small intestine through effects on enteric nerves and mast cells. Am J Physiol. 1995 Jul;269(1 Pt 1):G85-92.  

[3]. P Cornaglia-Ferraris, et al. Sensory neuropeptides (substance P) and 4-11 SP enhance human neutrophils chemiluminescence; the role of L-arginine. Int J Immunopharmacol. 1986;8(4):463-8.  

Chemical & Physical Properties

[ Density]:
1.266g/cm3

[ Boiling Point ]:
1470.1ºC at 760mmHg

[ Molecular Formula ]:
C46H67N11O10S

[ Molecular Weight ]:
966.15700

[ Flash Point ]:
842.9ºC

[ Exact Mass ]:
965.47900

[ PSA ]:
370.30000

[ LogP ]:
3.23030

[ Index of Refraction ]:
1.578

Related Compounds