[D-Pro4,D-Trp7,9,Nle11]-Substance P (4-11)

Names

[ Name ]:
[D-Pro4,D-Trp7,9,Nle11]-Substance P (4-11)

[Synonym ]:
4-Pro-7,9-Trp-11-nle-substance p (4-11)
substance P (4-11),Pro(4)-Trp(7,9)-Nle(11)
Substance P,fragment 4-11,[D-Pro4,D-Trp7,9,Nle11]
(D-pro4,D-trp7,9,nle11)-substance P*fragment 4-11
Pttnl-sp(4-11)
H-D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-NLE-NH2
SUBSTANCE P [D-PRO4,D-TRP7,9,NLE11]-FRAGMENT 4-11
D-Pro-L-Gln-L-Gln-D-Trp-L-Phe-D-Trp-L-Leu-L-Nle-NH2
(D-PRO4,D-TRP7,9,NLE11)-SUBSTANCE P (4-11)
D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-NLE-NH2

Biological Activity

[Description]:

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist. [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) inhibits the effects of gold-protein-substance P (GPSP) and substance P (SP)[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[In Vitro]

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) (100 nM) dose not exert a direct relaxant or contractile effect, but significantly reduces the vasodilatation induced by SP and GPSP[1].

[References]

[1]. Cathieni M M, et al. Pharmacological Evidence that Gold-Protein-Substance P Complex Activates Neurokinin NK1 Receptors[J]. Cellular Physiology & Biochemistry, 1995, 5(2):85-95.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₈H₇₇N₁₃O₁₀

[ Molecular Weight ]:
1116.31000

[ Exact Mass ]:
1115.59000

[ PSA ]:
376.58000

[ LogP ]:
6.24130

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

A new analogue of substance P with antagonistic properties in renal and pulmonary arteries.

Acta Physiol. 15 , 10, (1989)

The effects of a new analogue of substance P (SP-A) and its interaction with substance P (SP) were studied in vitro isolated preparations from rabbit renal arteries and rat renal and pulmonary arterie...

Synthesis of substance P antagonists: [D-Pro4, D-Trp7,9,Nle11]-substance P(4-11).

Pharmazie 39(1) , 65-7, (1984)