m-PEG5-Tos

Modify Date: 2025-08-26 19:45:53

m-PEG5-Tos structure	Common Name	m-PEG5-Tos
	CAS Number	80755-67-5	Molecular Weight	424.50600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₃₀O₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of m-PEG5-Tos

m-PEG5-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-c). m-PEG5-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277)[1].

Name	2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol,4-methylbenzenesulfonic acid
Synonym	More Synonyms

Description	m-PEG5-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-c). m-PEG5-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Yuxia Zhao, et al. Derivative of silybin ethers, and synthetic method and application thereof. Patent CN105037337A.

Molecular Formula	C₁₈H₃₀O₈S
Molecular Weight	424.50600
Exact Mass	424.17700
PSA	129.13000
LogP	2.01400
Storage condition	2-8°C

Pentaethylene g...

CAS#:23778-52-1

Tosyl chloride

CAS#:98-59-9

~99%

m-PEG5-Tos

CAS#:80755-67-5

Literature: Wolfe, Amanda L.; Duncan, Katharine K.; Lajiness, James P.; Zhu, Kaicheng; Duerfeldt, Adam S.; Boger, Dale L. Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6845 - 6857

Pentaethylene glycol

CAS#:4792-15-8

m-PEG5-Tos

CAS#:80755-67-5

Literature: Ajayaghosh, Ayyappanpillai; Arunkumar, Easwaran Organic Letters, 2005 , vol. 7, # 15 p. 3135 - 3138

m-PEG3-OH

CAS#:112-35-6

m-PEG5-Tos

CAS#:80755-67-5

Literature: Kocian, Oldrich; Chiu, Kwok W.; Demeure, Roger; Gallez, Bernard; Jones, Christopher J.; Thornback, John R. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 5 p. 527 - 536

2-[2-[2-[2-[2-(...

CAS#:146395-16-6

m-PEG5-Tos

CAS#:80755-67-5

BnO-PEG5-OH

CAS#:57671-28-0

m-PEG5-Tos

CAS#:80755-67-5

Literature: Selve, Claude; Achilefu, Samuel Journal of the Chemical Society, Chemical Communications, 1990 , # 13 p. 911 - 912

1-benzyl-15-met...

CAS#:155887-95-9

m-PEG5-Tos

CAS#:80755-67-5

Literature: Selve, Claude; Achilefu, Samuel Journal of the Chemical Society, Chemical Communications, 1990 , # 13 p. 911 - 912

Precursor 6
CAS#:23778-52-1 Pentaethylene g... CAS#:98-59-9 Tosyl chloride CAS#:4792-15-8 Pentaethylene glycol CAS#:112-35-6 m-PEG3-OH
CAS#:146395-16-6 2-[2-[2-[2-[2-(... CAS#:57671-28-0 BnO-PEG5-OH
DownStream 1
CAS#:5498-83-9 m-PEG5-NH2

2,5,8,11,14-Pentaoxahexadecan-16-ol,4-methylbenzenesulfonate

pentaethylene glycol mono methyl ether tosylate

pentaethyleneglycol monomethyl ether monotosylate

pentaethyleneglycol momomethyl ether tosylate

14-methoxy-3,6,9,12-tetraoxatetradecyl toluene-p-sulfonate

TsO(CH2CH2O)5Me

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m-PEG5-Tos

Use of m-PEG5-Tos

Names

m-PEG5-Tos Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.