874208-94-3

874208-94-3 structure

Name: m-PEG5-NHS ester
Chemical Name: 3-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid 2.5-dioxo-pyrrolidin-1-yl ester
CAS Number: 874208-94-3
Molecular Formula: C₁₆H₂₇NO₉
Molecular Weight: 377.38700
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-08-30 19:55:18
Modify Date: 2024-01-07 10:16:27
m-PEG5-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Name	3-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid 2.5-dioxo-pyrrolidin-1-yl ester
Synonyms	m-peg5-nhs ester

Description	m-PEG5-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.