m-PEG5-Tos

Names

[ Name ]:
m-PEG5-Tos

[Synonym ]:
2,5,8,11,14-Pentaoxahexadecan-16-ol,4-methylbenzenesulfonate
pentaethylene glycol mono methyl ether tosylate
pentaethyleneglycol monomethyl ether monotosylate
pentaethyleneglycol momomethyl ether tosylate
14-methoxy-3,6,9,12-tetraoxatetradecyl toluene-p-sulfonate
TsO(CH2CH2O)5Me

Biological Activity

[Description]:

m-PEG5-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-c). m-PEG5-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Yuxia Zhao, et al. Derivative of silybin ethers, and synthetic method and application thereof. Patent CN105037337A.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₃₀O₈S

[ Molecular Weight ]:
424.50600

[ Exact Mass ]:
424.17700

[ PSA ]:
129.13000

[ LogP ]:
2.01400

[ Storage condition ]:
2-8°C

m-PEG5-Tos

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds