m-PEG5-Tos

Names

[ Name ]:
m-PEG5-Tos

[Synonym ]:
2,5,8,11,14-Pentaoxahexadecan-16-ol,4-methylbenzenesulfonate
pentaethylene glycol mono methyl ether tosylate
pentaethyleneglycol monomethyl ether monotosylate
pentaethyleneglycol momomethyl ether tosylate
14-methoxy-3,6,9,12-tetraoxatetradecyl toluene-p-sulfonate
TsO(CH2CH2O)5Me

Biological Activity

[Description]:

m-PEG5-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-c). m-PEG5-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Yuxia Zhao, et al. Derivative of silybin ethers, and synthetic method and application thereof. Patent CN105037337A.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₃₀O₈S

[ Molecular Weight ]:
424.50600

[ Exact Mass ]:
424.17700

[ PSA ]:
129.13000

[ LogP ]:
2.01400

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.