BnO-PEG5-OH

Names

[ Name ]:
BnO-PEG5-OH

[Synonym ]:
2,5,8,11,14-Pentaoxahexadecan-16-ol, 1-phenyl-
1-Phenyl-2,5,8,11,14-pentaoxahexadecan-16-ol
2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol

Biological Activity

[Description]:

BnO-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Girardini M, et al. Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs. Bioorg Med Chem. 2019 Jun 15;27(12):2466-2479.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
437.2±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₈O₆

[ Molecular Weight ]:
328.401

[ Flash Point ]:
218.2±27.3 °C

[ Exact Mass ]:
328.188599

[ PSA ]:
66.38000

[ LogP ]:
-0.18

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.497

MSDS

Click to get detail MSDS

Safety Information

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%