HO-PEG11-OH

Names

[ CAS No. ]:
6809-70-7

[ Name ]:
HO-PEG11-OH

[Synonym ]:
EINECS 229-884-8
3,6,9,12,15,18,21,24,27,30-Decaoxadotriacontane-1,32-diol
Undecaethylene glycol

Biological Activity

[Description]:

HO-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.116g/cm3

[ Boiling Point ]:
571.4ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₄₆O₁₂

[ Molecular Weight ]:
502.59300

[ Flash Point ]:
299.3ºC

[ Exact Mass ]:
502.29900

[ PSA ]:
132.76000

[ Index of Refraction ]:
1.465

Safety Information

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%