Propargyl-PEG5-OH

Names

[ CAS No. ]:
1036204-60-0

[ Name ]:
Propargyl-PEG5-OH

[Synonym ]:
3,6,9,12,15-Pentaoxaoctadec-17-yn-1-ol

Biological Activity

[Description]:

Propargyl-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Robert Zamboni, et al. Raf-degrading conjugate compounds. WO2018200981A1.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
368.1±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₂₄O₆

[ Molecular Weight ]:
276.326

[ Flash Point ]:
176.4±26.5 °C

[ Exact Mass ]:
276.157288

[ LogP ]:
-1.68

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.461

[ Storage condition ]:
2-8°C

Propargyl-PEG5-OH

Names

Biological Activity

Chemical & Physical Properties

Related Compounds