Pentaethylene glycol monomethyl ether

Names

[ Name ]:
Pentaethylene glycol monomethyl ether

[Synonym ]:
2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol
2,5,8,11,14-Pentaoxahexadecan-16-ol
1PG
3,6,9,12,15-pentaoxahexadecanol
PENTAETHYLENE GLYCOL MONOMETHYL ETHER
3,6,9,12,15-Pentaoxahexadecan-1-ol
14-methoxy-3,6,9,12-tetraoxa-tetradecan-1-ol

Biological Activity

[Description]:

Pentaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
332.3±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₂₄O₆

[ Molecular Weight ]:
252.305

[ Flash Point ]:
154.7±25.1 °C

[ Exact Mass ]:
252.157288

[ PSA ]:
66.38000

[ LogP ]:
-2.23

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.441

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36/37/39

[ HS Code ]:
2909499000

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%