m-PEG4-CH2COOH

Names

[ Name ]:
m-PEG4-CH2COOH

[Synonym ]:
3,6,9,12,15-pentoxahexadecanoic acid
MPEG4-acetic acid
(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)acetic acid
3,6,9,12,15-Pentaoxahexadecansaeure
EINECS 240-163-7
3,6,9,12,15-Pentaoxahexadecanoicacid
2,5,8,11,14-Pentaoxahexadecan-16-oic acid

Biological Activity

[Description]:

m-PEG4-CH2COOH is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. TaoDeng, et al. Monodisperse oligoethylene glycols modified Propofol prodrugs. Bioorganic & Medicinal Chemistry Letters.

Chemical & Physical Properties

[ Density]:
1.125g/cm3

[ Boiling Point ]:
379.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₂₂O₇

[ Molecular Weight ]:
266.28800

[ Flash Point ]:
137.1ºC

[ Exact Mass ]:
266.13700

[ PSA ]:
83.45000

[ Vapour Pressure ]:
8.24E-07mmHg at 25°C

[ Index of Refraction ]:
1.447

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%