Nonaethylene glycol monomethyl ether

Names

[ Name ]:
Nonaethylene glycol monomethyl ether

[Synonym ]:
Nonaethylene Glycol Monomethyl Ether
O-methyl-nonaethyleneglycol
O-Methyl-nonaaethylenglykol
3,6,9,12,15,18,21,24,27-Nonaoxaoctacosan-1-ol
3,6,9,12,15,18,21,24,27-Nonaoxaoctacosanol
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol
O-methyl-nonaaethylene glycol
Nonaethylene glycol monomethyl ether
MPEG9-OH

Biological Activity

[Description]:

Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
490.1±40.0 °C at 760 mmHg

[ Melting Point ]:
14ºC

[ Molecular Formula ]:
C₁₉H₄₀O₁₀

[ Molecular Weight ]:
428.515

[ Flash Point ]:
250.2±27.3 °C

[ Exact Mass ]:
428.262146

[ PSA ]:
103.30000

[ LogP ]:
-3.66

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.453

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ HS Code ]:
2909440000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Related Compounds

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