Glycolic acid

Glycolic acid Structure
Glycolic acid
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Common Name Glycolic acid
CAS Number 79-14-1 Molecular Weight 76.051
Density 1.4±0.1 g/cm3 Boiling Point 265.6±13.0 °C at 760 mmHg
Molecular Formula C2H4O3 Melting Point 75-80 °C(lit.)
MSDS Chinese USA Flash Point 128.7±16.3 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Use of Glycolic acid


Glycolic Acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

 Names

Name glycolic acid
Synonym More Synonyms

 Glycolic acid Biological Activity

Description Glycolic Acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Different concentrations of Glycolic Acid (GA) or LA (300 and 500 mg/mL) are tested on the growth of mouse and human melanoma cells. Both types of cells grow well, even in the presence of 300 mg/mL of each chemical for 5 days. However, 500 mg/mL Glycolic Acid inhibits the cell growth of mouse melanoma cells (41%) and humanmelanoma cells (27%), and 500 mg/mL of LA inhibits the growth of mouse melanoma cells (36%)[1].
Solvent
In Vitro:

10 mM in DMSO

Solubility
1 mM 13.1492 mL 65.7462 mL 131.4924 mL
5 mM 2.6298 mL 13.1492 mL 26.2985 mL
10 mM 1.3149 mL 6.5746 mL 13.1492 mL
Cell Assay HM3KO pigmented human melanoma cells and B16 mouse melanoma cells are cultured in Dulbecco’s modified Eagles medium supplemented with 10%fetal calf serum and appropriate amounts of antibiotics and fungizone were dissolved at a concentration of 100mg/mL in distilled water. These chemicals (e.g., Glycolic Acid ) are added to the cell cultures at final concentrations of 300 or 500 mg/mL every 2 days for 5 days[1].
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
SMILES O=C(O)CO
References

[1]. Usuki A, et al. The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells. Exp Dermatol. 2003;12 Suppl 2:43-50.

Related Molecules 3-Methyladenine | Hydrocortisone | Acetylcysteine | Tretinoin | Melatonine | Prostaglandin E2 | Nicotinamide | Adenosine triphosphate | 4-Acetamidophenol | Prostaglandin E1 | Dehydroepiandrosterone | Corticosterone | Progesterone | Docosahexaenoic Acid | NAD+
Related Doc

SDS |COA |HNMR

*The above documents are provided by Medchemexpress and are for scientific research only.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 265.6±13.0 °C at 760 mmHg
Melting Point 75-80 °C(lit.)
Molecular Formula C2H4O3
Molecular Weight 76.051
Flash Point 128.7±16.3 °C
Exact Mass 76.016045
PSA 57.53000
LogP -1.05
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.450
Storage condition 2-8°C
Stability Stable. Incompatible with bases, oxidizing agents and reducing agents.
Water Solubility SOLUBLE

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MC5250000
CHEMICAL NAME :
Glycolic acid
CAS REGISTRY NUMBER :
79-14-1
BEILSTEIN REFERENCE NO. :
1209322
LAST UPDATED :
199801
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C2-H4-O3
MOLECULAR WEIGHT :
76.06
WISWESSER LINE NOTATION :
QV1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1950 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,656,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1920 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2480 gm/kg/35W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 84,183,1959
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/m3/6H/2W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0546415 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
9 gm/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 53,117,1996 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 35260 No. of Facilities: 2991 (estimated) No. of Industries: 27 No. of Occupations: 29 No. of Employees: 29291 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 35260 No. of Facilities: 5782 (estimated) No. of Industries: 64 No. of Occupations: 63 No. of Employees: 191563 (estimated) No. of Female Employees: 98538 (estimated)

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H314-H332
Precautionary Statements P261-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C:Corrosive
Risk Phrases R22;R34
Safety Phrases S26-S36/37/39-S45-S23
RIDADR UN 3265 8/PG 3
WGK Germany 1
RTECS MC5250000
Packaging Group II
Hazard Class 8
HS Code 2918199090

 Synthetic Route

 Customs

HS Code 2918199090
Summary 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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