[D-Pro2,D-Phe7,D-Trp9]-Substance P

Modify Date: 2025-09-17 08:50:44

[D-Pro2,D-Phe7,D-Trp9]-Substance P Structure
[D-Pro2,D-Phe7,D-Trp9]-Substance P structure
 Common Name [D-Pro2,D-Phe7,D-Trp9]-Substance P
CAS Number 77275-70-8 Molecular Weight 1476.79000
Density N/A Boiling Point N/A
Molecular Formula C72H105N19O13S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of [D-Pro2,D-Phe7,D-Trp9]-Substance P


[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly[1][2].

 Names

Name [D-Pro2,D-Phe7,D-Trp9]-Substance P
Synonym More Synonyms

 [D-Pro2,D-Phe7,D-Trp9]-Substance P Biological Activity

Description [D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly[1][2].
Related Catalog
Target

Substance P[2]

In Vitro [D-Pro2,D-Phe7,D-Trp9] Substance P (10-100 μM; 2 min or 10 min) produces dose-related contractions of the guinea-pig ileum and in the rabbit external jugular vein[1].
In Vivo [D-Pro2,D-Phe7,D-Trp9] Substance P (1-2 mg/kg; i.v.; once) inhibits the salivary secretion which was induced by Substance P in rats. In the dosage range at 1-1.5 mg/kg slightly increases the blood pressure[2].
References

[1]. Hawcock AB, et al. Agonist effects of [D-Pro2,D-Phe7,D-Trp9]substance P--evidence for different receptors. Eur J Pharmacol. 1982 May 7;80(1):135-8.  

[2]. Folkers K, et al. Chemical design of antagonists of substance P. Acta Physiol Scand. 1981 Apr;111(4):505-6.  

 Chemical & Physical Properties

Molecular Formula C72H105N19O13S
Molecular Weight 1476.79000
Exact Mass 1475.79000
PSA 557.72000
LogP 6.28670

 Synonyms

substance P,Pro(2)-Phe(7)-Trp(9)
Substance P,(D-Pro2,D-Phe7,D-Trp9)
ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2
(D-PROLINE2,D-PHENYLALANINE7,D-TRYPTOPHAN9)SUBSTANCE P)
(D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P
H-ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2
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Chemsrc provides [D-Pro2,D-Phe7,D-Trp9]-Substance P(CAS#:77275-70-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of [D-Pro2,D-Phe7,D-Trp9]-Substance P are included as well.>> amp version: [D-Pro2,D-Phe7,D-Trp9]-Substance P

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