109212-72-8

109212-72-8 structure

Name: (D-Pro2,D-Trp6.8,Nle10)-Neurokinin B
Chemical Name: [D-Pro2, D-Trp6,8, Nle10]-Neurokinin B,DpHDFwVwL-Nle-NH2
CAS Number: 109212-72-8
Molecular Formula: C₆₇H₈₇N₁₅O₁₄
Molecular Weight: 1326.50000
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2018-12-25 21:17:29
Modify Date: 2024-01-27 13:10:29
(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A[1].

Name	[D-Pro2, D-Trp6,8, Nle10]-Neurokinin B,DpHDFwVwL-Nle-NH2
Synonyms	ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2 (D-PRO2,D-TRP6,8,NLE10)-NEUROKININ B (D-Pro2,D-Trp6 DPHDFWVWL-NLE-NH2 H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2

Description	(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
In Vivo	在大鼠中，(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B (1 mg/kg i.v.) 显着减少 Substance P- 和 Neurokinin B-，但不减少乙酰胆碱或 Neurokinin A 诱导的流涎。(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B 可将麻醉大鼠的血压降低 35% 至 40%[2]。
References	[1]. H I Jacoby, et al. Differentiation of multiple neurokinin receptors in the guinea pig ileum. Life Sci. 1986 Nov 24;39(21):1995-2003. [2]. C W Murray, et al. Neurokinin-induced salivation in the anesthetized rat: a three receptor hypothesis. J Pharmacol Exp Ther. 1987 Aug;242(2):500-6.