Fomepizole

Modify Date: 2024-01-02 19:31:41

Fomepizole structure	Common Name	Fomepizole
	CAS Number	7554-65-6	Molecular Weight	82.104
	Density	1.1±0.1 g/cm3	Boiling Point	243.6±0.0 °C at 760 mmHg
	Molecular Formula	C₄H₆N₂	Melting Point	13°C
	MSDS	Chinese USA	Flash Point	96.1±0.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of Fomepizole

Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol.

Name	fomepizole
Synonym	More Synonyms

Description	Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170. [2]. Lepik KJ, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Ann Emerg Med. 2009 Apr;53(4):439-450.e10.

Description

Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol.

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Others

References

[1]. Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170.

[2]. Lepik KJ, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Ann Emerg Med. 2009 Apr;53(4):439-450.e10.

Density	1.1±0.1 g/cm3
Boiling Point	243.6±0.0 °C at 760 mmHg
Melting Point	13°C
Molecular Formula	C₄H₆N₂
Molecular Weight	82.104
Flash Point	96.1±0.0 °C
Exact Mass	82.053101
PSA	28.68000
LogP	0.78
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.523
Storage condition	2-8°C
Water Solubility	soluble

Fomepizole MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ7350000

CHEMICAL NAME :: Pyrazole, 4-methyl-

CAS REGISTRY NUMBER :: 7554-65-6

BEILSTEIN REFERENCE NO. :: 0105204

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H6-N2

MOLECULAR WEIGHT :: 82.12

WISWESSER LINE NOTATION :: T5MNJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 534 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 28,1198,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 310 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 28,1198,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 28,1198,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 310 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 28,1198,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg/4D-I

TOXIC EFFECTS :: Behavioral - fluid intake Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 39,513,1976

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36-S24/25
RIDADR	2810
WGK Germany	3
RTECS	UQ7350000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933199090

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Fomepizole

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Literature: Reardan, Dayton T.; Combe, Michel D. Patent: US2007/244330 A1, 2007 ; Location in patent: Page/Page column 2; 3 ;

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Precursor 2
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DownStream 6
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HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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4-Methylpyrazol

4-MP

EINECS 231-445-0

Fomepizolefreebase

4-methyl-pyrazol

Antizol-Vet

1H-4-methylpyrazole

4-Methyl-1H-pyrazole

Antizol

4-METHYLPYRRAZOLE

3-methyl-1H-pyrazole

1H-Pyrazole, 4-methyl-

4-Methylpyrazole

T5MNJ D1

4-methyl-1H-pyrazol

Fomepizole

fomepizol

MFCD00005245

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Fomepizole
Price: ￥88.0/1g ￥238.0/5g
Purity: 97.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Fomepizole
Price: $100.0/100mg $200.0/250mg $400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Fomepizole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 4-Methylpyrazole
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-Methylpyrazole
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Fomepizole

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