SCH 50911

Modify Date: 2025-08-25 12:30:14

SCH 50911 Structure
SCH 50911 structure
Common Name SCH 50911
CAS Number 733717-87-8 Molecular Weight 173.21000
Density N/A Boiling Point N/A
Molecular Formula C8H15NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SCH 50911


SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM[1].

 Names

Name sch 50,911
Synonym More Synonyms

 SCH 50911 Biological Activity

Description SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM[1].
Related Catalog
Target

GABA(B):1.1 μM (IC50)

References

[1]. Ong J, et al. The morpholino-acetic acid analogue Sch 50911 is a selective GABA(B) receptor antagonist in rat neocortical slices. Eur J Pharmacol. 1998 Nov 27;362(1):35-41.

 Chemical & Physical Properties

Molecular Formula C8H15NO3
Molecular Weight 173.21000
Exact Mass 173.10500
PSA 58.56000
LogP 0.55690

 Synonyms

SCH-50911
Sch 50911
(+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid
(2S)-(+)-5,5-dimethyl-2-morpholineacetic acid
SCH 50911
(2S)-5,5-dimethyl-2-morpholineacetic acid
WS 3
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