MeOSuc-Ala-Ala-Pro-Val-pNA

Modify Date: 2025-08-30 15:01:14

MeOSuc-Ala-Ala-Pro-Val-pNA Structure
MeOSuc-Ala-Ala-Pro-Val-pNA structure
 Common Name MeOSuc-Ala-Ala-Pro-Val-pNA
CAS Number 70967-90-7 Molecular Weight 590.62500
Density 1.297g/cm3 Boiling Point 908.4ºC at 760 mmHg
Molecular Formula C27H38N6O9 Melting Point N/A
MSDS USA Flash Point 503.2ºC

 Use of MeOSuc-Ala-Ala-Pro-Val-pNA


MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive fluorogenic substrate of human leukocyte and porcine pancreatic elastase[1].

 Names

Name methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-methyl-1-(4-nitroanilino)-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate
Synonym More Synonyms

 MeOSuc-Ala-Ala-Pro-Val-pNA Biological Activity

Description MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive fluorogenic substrate of human leukocyte and porcine pancreatic elastase[1].
Related Catalog
In Vitro MeOSuc-Ala-Ala-Pro-Val-pNA exhibits kc/Km values of 185,000, 15,000, 58,000 and 330,000 M-1s-1 at 0.10 M phosphate, 0.20 M Mes, 0.10 M phosphate and 0.04 M phosphate, respectively, for reactions of human leukocyte elastase[2].
References

[1]. Castillo MJ, et al. Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases. Anal Biochem. 1979 Oct 15;99(1):53-64.

[2]. Ross L. Stein, et al. Catalysis by human leukocyte elastase. Rate-limiting deacylation for specific p-nitroanilides and amides. J. Am. Chem. Soc. 1984, 106, 3, 796-798.

 Chemical & Physical Properties

Density 1.297g/cm3
Boiling Point 908.4ºC at 760 mmHg
Molecular Formula C27H38N6O9
Molecular Weight 590.62500
Flash Point 503.2ºC
Exact Mass 590.27000
PSA 208.83000
LogP 2.33450
Index of Refraction 1.567
Storage condition 20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport

 Synthetic Route

diazomethane structure

diazomethane

CAS#:186581-53-3

Suc-Ala-Ala-Pro-Val-pNA structure

Suc-Ala-Ala-Pro...

CAS#:72682-76-9

~87%

MeOSuc-Ala-Ala-Pro-Val-pNA Structure

MeOSuc-Ala-Ala-...

CAS#:70967-90-7

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
Z-Ala-Ala-OH structure

Z-Ala-Ala-OH

CAS#:16012-70-7

~%

MeOSuc-Ala-Ala-Pro-Val-pNA Structure

MeOSuc-Ala-Ala-...

CAS#:70967-90-7

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
N-carbpbenzoxy-alanine pentafluorophenyl ester structure

N-carbpbenzoxy-...

CAS#:90105-39-8

~%

MeOSuc-Ala-Ala-Pro-Val-pNA Structure

MeOSuc-Ala-Ala-...

CAS#:70967-90-7

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
N-carbobenzoxy-alanyl-alanyl-prolyl-valine p-nitroanilide structure

N-carbobenzoxy-...

CAS#:90105-43-4

~%

MeOSuc-Ala-Ala-Pro-Val-pNA Structure

MeOSuc-Ala-Ala-...

CAS#:70967-90-7

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
(2S)-1-[(2S)-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoyl]pyrrolidine-2-carboxylic acid structure

(2S)-1-[(2S)-2-...

CAS#:61430-05-5

~%

MeOSuc-Ala-Ala-Pro-Val-pNA Structure

MeOSuc-Ala-Ala-...

CAS#:70967-90-7

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
(2S)-1-[(2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoyl]-N-[(2S)-3-methyl-1-(4-nitroanilino)-1-oxobutan-2-yl]pyrrolidine-2-carboxamide structure

(2S)-1-[(2S)-2-...

CAS#:90105-48-9

~%

MeOSuc-Ala-Ala-Pro-Val-pNA Structure

MeOSuc-Ala-Ala-...

CAS#:70967-90-7

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388

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 Synonyms

MFCD00077137
N-(Methoxysuccinyl)-Ala-Ala-Pro-Val 4-nitroanilide
MeOSuc-Ala-Ala-Pro-Val-p-NA
N-methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide
MeO-Suc-Ala-Ala-Pro-Val-(p-nitroanilide)
N-3-carbomethoxypropanoyl-alanyl-alanyl-prolyl-valine p-nitroanilide
MeOSuc-AAPV-PNA
N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine 4-nitroanilide
EINECS 232-670-7
MeOSuc-Ala-Ala-Pro-Val-pNA
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