MeOSuc-Ala-Ala-Pro-Val-pNA
MeOSuc-Ala-Ala-Pro-Val-pNA structure
|
Common Name | MeOSuc-Ala-Ala-Pro-Val-pNA | ||
|---|---|---|---|---|
| CAS Number | 70967-90-7 | Molecular Weight | 590.62500 | |
| Density | 1.297g/cm3 | Boiling Point | 908.4ºC at 760 mmHg | |
| Molecular Formula | C27H38N6O9 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 503.2ºC | |
Use of MeOSuc-Ala-Ala-Pro-Val-pNAMeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive fluorogenic substrate of human leukocyte and porcine pancreatic elastase[1]. |
| Name | methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-methyl-1-(4-nitroanilino)-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate |
|---|---|
| Synonym | More Synonyms |
| Description | MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive fluorogenic substrate of human leukocyte and porcine pancreatic elastase[1]. |
|---|---|
| Related Catalog | |
| In Vitro | MeOSuc-Ala-Ala-Pro-Val-pNA exhibits kc/Km values of 185,000, 15,000, 58,000 and 330,000 M-1s-1 at 0.10 M phosphate, 0.20 M Mes, 0.10 M phosphate and 0.04 M phosphate, respectively, for reactions of human leukocyte elastase[2]. |
| References |
| Density | 1.297g/cm3 |
|---|---|
| Boiling Point | 908.4ºC at 760 mmHg |
| Molecular Formula | C27H38N6O9 |
| Molecular Weight | 590.62500 |
| Flash Point | 503.2ºC |
| Exact Mass | 590.27000 |
| PSA | 208.83000 |
| LogP | 2.33450 |
| Index of Refraction | 1.567 |
| Storage condition | 20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
|
~87%
MeOSuc-Ala-Ala-... CAS#:70967-90-7 |
| Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388 |
|
~%
MeOSuc-Ala-Ala-... CAS#:70967-90-7 |
| Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388 |
|
~%
MeOSuc-Ala-Ala-... CAS#:70967-90-7 |
| Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388 |
|
~%
MeOSuc-Ala-Ala-... CAS#:70967-90-7 |
| Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388 |
|
~%
MeOSuc-Ala-Ala-... CAS#:70967-90-7 |
| Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388 |
|
~%
MeOSuc-Ala-Ala-... CAS#:70967-90-7 |
| Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388 |
![(2S)-1-[(2S)-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoyl]pyrrolidine-2-carboxylic acid structure](https://image.chemsrc.com/caspic/072/61430-05-5.png)
![(2S)-1-[(2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoyl]-N-[(2S)-3-methyl-1-(4-nitroanilino)-1-oxobutan-2-yl]pyrrolidine-2-carboxamide structure](https://image.chemsrc.com/caspic/370/90105-48-9.png)
CAS#:100-01-6|
Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection.
Mucosal Immunol. 8 , 896-905, (2015) Neutrophil elastase (NE) and cathepsin G (CG) contribute to intracellular microbial killing but, if left unchecked and released extracellularly, promote tissue damage. Conversely, mechanisms that cons... |
|
|
Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones.
PLoS ONE 7 , e32366, (2012) Neutrophils play an important role in innate immunity by defending the host organism against invading microorganisms. Antimicrobial activity of neutrophils is mediated by release of antimicrobial pept... |
|
|
Inhibition of elastase by a synthetic cotton-bound serine protease inhibitor: in vitro kinetics and inhibitor release.
Wound Repair Regen. 7(2) , 106-18, (1999) A cotton-bound serine protease inhibitor of elastase (fiber-inhibitor) has been formulated for in vitro evaluation in chronic wound fluid. As a model to understand the properties of the inhibitor in w... |
| MFCD00077137 |
| N-(Methoxysuccinyl)-Ala-Ala-Pro-Val 4-nitroanilide |
| MeOSuc-Ala-Ala-Pro-Val-p-NA |
| N-methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide |
| MeO-Suc-Ala-Ala-Pro-Val-(p-nitroanilide) |
| N-3-carbomethoxypropanoyl-alanyl-alanyl-prolyl-valine p-nitroanilide |
| MeOSuc-AAPV-PNA |
| N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine 4-nitroanilide |
| EINECS 232-670-7 |
| MeOSuc-Ala-Ala-Pro-Val-pNA |