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70967-90-7

70967-90-7 structure
70967-90-7 structure
  • Name: MeOSuc-Ala-Ala-Pro-Val-pNA
  • Chemical Name: methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-methyl-1-(4-nitroanilino)-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate
  • CAS Number: 70967-90-7
  • Molecular Formula: C27H38N6O9
  • Molecular Weight: 590.62500
  • Catalog: Research Areas Others
  • Create Date: 2018-10-05 12:11:34
  • Modify Date: 2025-08-30 15:01:14
  • MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive fluorogenic substrate of human leukocyte and porcine pancreatic elastase[1].
Name methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-methyl-1-(4-nitroanilino)-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate
Synonyms MFCD00077137
N-(Methoxysuccinyl)-Ala-Ala-Pro-Val 4-nitroanilide
MeOSuc-Ala-Ala-Pro-Val-p-NA
N-methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide
MeO-Suc-Ala-Ala-Pro-Val-(p-nitroanilide)
N-3-carbomethoxypropanoyl-alanyl-alanyl-prolyl-valine p-nitroanilide
MeOSuc-AAPV-PNA
N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine 4-nitroanilide
EINECS 232-670-7
MeOSuc-Ala-Ala-Pro-Val-pNA
Description MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive fluorogenic substrate of human leukocyte and porcine pancreatic elastase[1].
Related Catalog
In Vitro MeOSuc-Ala-Ala-Pro-Val-pNA exhibits kc/Km values of 185,000, 15,000, 58,000 and 330,000 M-1s-1 at 0.10 M phosphate, 0.20 M Mes, 0.10 M phosphate and 0.04 M phosphate, respectively, for reactions of human leukocyte elastase[2].
References

[1]. Castillo MJ, et al. Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases. Anal Biochem. 1979 Oct 15;99(1):53-64.

[2]. Ross L. Stein, et al. Catalysis by human leukocyte elastase. Rate-limiting deacylation for specific p-nitroanilides and amides. J. Am. Chem. Soc. 1984, 106, 3, 796-798.
Density 1.297g/cm3
Boiling Point 908.4ºC at 760 mmHg
Molecular Formula C27H38N6O9
Molecular Weight 590.62500
Flash Point 503.2ºC
Exact Mass 590.27000
PSA 208.83000
LogP 2.33450
Index of Refraction 1.567
Storage condition 20°C
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
186581-53-3 structure

186581-53-3

72682-76-9 structure

72682-76-9

~87%

70967-90-7 structure

70967-90-7

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
16012-70-7 structure

16012-70-7

~%

70967-90-7 structure

70967-90-7

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
90105-39-8 structure

90105-39-8

~%

70967-90-7 structure

70967-90-7

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
90105-43-4 structure

90105-43-4

~%

70967-90-7 structure

70967-90-7

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
61430-05-5 structure

61430-05-5

~%

70967-90-7 structure

70967-90-7

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
90105-48-9 structure

90105-48-9

~%

70967-90-7 structure

70967-90-7

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
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