BMS 986187
Modify Date: 2024-01-03 11:07:33
BMS 986187 structure
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Common Name | BMS 986187 | ||
|---|---|---|---|---|
| CAS Number | 684238-37-7 | Molecular Weight | 470.599 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 627.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C31H34O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 265.5±31.5 °C | |
Use of BMS 986187BMS-986187 is an δ-opioid receptor-selective positive allosteric modulator (PAM) with an EC50 of 0.03 μM and a pKB of 6.02 (∼1 μM). BMS-986187 has no observable PAM activity at the μ-receptor (EC50=3 μM)[1]. |
| Name | 684238-37-7 |
|---|---|
| Synonym | More Synonyms |
| Description | BMS-986187 is an δ-opioid receptor-selective positive allosteric modulator (PAM) with an EC50 of 0.03 μM and a pKB of 6.02 (∼1 μM). BMS-986187 has no observable PAM activity at the μ-receptor (EC50=3 μM)[1]. |
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| Related Catalog | |
| In Vitro | BMS-986187 (1 nM-100 uM) produces little or no activity in agonist mode, but in PAM mode (in the presence of an EC20 of leu-enkephalin (in CHO-OPRD1 cells) or endomorphin 1 (in CHO-OPRM1 cells)) produces a response with an EC50 of 48 nM in CHO-OPRD1 cells and 2 μM in CHO-OPRM1 cells[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 627.0±55.0 °C at 760 mmHg |
| Molecular Formula | C31H34O4 |
| Molecular Weight | 470.599 |
| Flash Point | 265.5±31.5 °C |
| Exact Mass | 470.245697 |
| LogP | 6.19 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.604 |
| Storage condition | -20°C |
| 1H-Xanthene-1,8(2H)-dione, 3,4,5,6,7,9-hexahydro-3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]- |
| 3,3,6,6-Tetramethyl-9-{4-[(2-methylbenzyl)oxy]phenyl}-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione |