1-Methyl-2-nonylquinolin-4(1H)-one

Modify Date: 2025-08-25 20:07:08

1-Methyl-2-nonylquinolin-4(1H)-one structure	Common Name	1-Methyl-2-nonylquinolin-4(1H)-one
	CAS Number	68353-24-2	Molecular Weight	285.424
	Density	1.0±0.1 g/cm3	Boiling Point	391.9±42.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₂₇NO	Melting Point	73-75℃
	MSDS	N/A	Flash Point	132.6±17.3 °C

Use of 1-Methyl-2-nonylquinolin-4(1H)-one

1-Methyl-2-nonyl-4(1H)-quinolone, a quinolone alkaloid, is a potent and selective MAO-B (monoamine oxidase) inhibitor. 1-Methyl-2-nonyl-4(1H)-quinolone exhibites inhibitory activity on leukotriene biosynthesis, with an IC50 of 12.1 μM[1][2].

Name	1-methyl-2-nonylquinolin-4-one
Synonym	More Synonyms

Description	1-Methyl-2-nonyl-4(1H)-quinolone, a quinolone alkaloid, is a potent and selective MAO-B (monoamine oxidase) inhibitor. 1-Methyl-2-nonyl-4(1H)-quinolone exhibites inhibitory activity on leukotriene biosynthesis, with an IC50 of 12.1 μM[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	MAO-B MAO-A
In Vitro	1-Methyl-2-nonyl-4(1H)-quinolone shows more potent inhibitory effects against MAO-B compared to MAO-A[1].
References	[1]. Han XH, et al. Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase. Arch Pharm Res. 2007 Apr;30(4):397-401. [2]. Adams M, et al. Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa. Planta Med. 2004 Oct;70(10):904-8.

Density	1.0±0.1 g/cm3
Boiling Point	391.9±42.0 °C at 760 mmHg
Melting Point	73-75℃
Molecular Formula	C₁₉H₂₇NO
Molecular Weight	285.424
Flash Point	132.6±17.3 °C
Exact Mass	285.209259
PSA	22.00000
LogP	6.09
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.524

Hazard Codes	Xi

2-Nonylquinolin...

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methyl iodide

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~10%

1-Methyl-2-nony...

CAS#:68353-24-2