SPDP

Modify Date: 2025-08-20 20:42:52

SPDP structure	Common Name	SPDP
	CAS Number	68181-17-9	Molecular Weight	312.365
	Density	1.5±0.1 g/cm3	Boiling Point	465.9±55.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₂N₂O₄S₂	Melting Point	84-86 °C(lit.)
	MSDS	Chinese USA	Flash Point	235.6±31.5 °C

Use of SPDP

SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .

Name	N-Succinimidyl 3-(2-Pyridyldithio)propionate
Synonym	More Synonyms

Description	SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Others

References

[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7.

[2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.

Density	1.5±0.1 g/cm3
Boiling Point	465.9±55.0 °C at 760 mmHg
Melting Point	84-86 °C(lit.)
Molecular Formula	C₁₂H₁₂N₂O₄S₂
Molecular Weight	312.365
Flash Point	235.6±31.5 °C
Exact Mass	312.023834
PSA	127.17000
LogP	0.99
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.650
Storage condition	−20°C
Water Solubility	acetone: 50 mg/mL

SPDP MSDS(Chinese)

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3

N-Hydroxysuccinimide

CAS#:6066-82-6

3-(2-Pyridyldit...

CAS#:68617-64-1

~79%

SPDP

CAS#:68181-17-9

Literature: Shval'e, A. F.; Ofitserov, V. I.; Samukov, V. V. J. Gen. Chem. USSR (Engl. Transl.), 1985 , vol. 55, # 9 p. 2152,1909 - 1910

N-Hydroxysuccinimide

CAS#:6066-82-6

N/A

CAS#:119023-08-4

~74%

SPDP

CAS#:68181-17-9

Literature: Loccufier, J.; Schacht, E. Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 7 p. 535 - 540

2,2′-Dipyridyl ...

CAS#:2127-03-9

SPDP

CAS#:68181-17-9

Literature: Journal of the American Chemical Society, , vol. 129, # 31 p. 9640 - 9649

2-Pyridinethiol

CAS#:2637-34-5

2,2′-Dipyridyl ...

CAS#:2127-03-9

3-Mercaptopropi...

CAS#:107-96-0

N/A

CAS#:221180-71-8

Detail

Literature: US4149003 A1, ;

pyridin-2-yl th...

CAS#:59089-57-5

SPDP

CAS#:68181-17-9

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 55, # 9 p. 2152,1909 - 1910

3-(2-pyridylthi...

CAS#:119023-07-3

SPDP

CAS#:68181-17-9

Literature: Bulletin des Societes Chimiques Belges, , vol. 97, # 7 p. 535 - 540

Precursor 6
CAS#:6066-82-6 N-Hydroxysuccinimide CAS#:68617-64-1 3-(2-Pyridyldit... CAS#:2127-03-9 2,2′-Dipyridyl ... CAS#:2637-34-5 2-Pyridinethiol
CAS#:107-96-0 3-Mercaptopropi... CAS#:59089-57-5 pyridin-2-yl th...
DownStream 0

Optical fiber nanotips coated with molecular beacons for DNA detection.

Sensors (Basel.) 15 , 9666-80, (2015)

Optical fiber sensors, thanks to their compactness, fast response and real-time measurements, have a large impact in the fields of life science research, drug discovery and medical diagnostics. In rec...

Immunoliposomes containing Soluble Leishmania Antigens (SLA) as a novel antigen delivery system in murine model of leishmaniasis.

Exp. Parasitol. 146 , 78-86, (2014)

Development of new generation of vaccines against leishmaniasis requires adjuvants to elicit the type and intensity of immune response needed for protection. The coupling of target-specific antibodies...

Evaluation of cathepsin B activity for degrading collagen IV using a surface plasmon resonance method and circular dichroism spectroscopy

J. Pharm. Biomed. Anal. 95 , 47-53, (2014)

Evaluation of cathepsin B activities for degrading collagen IV and heat-denatured collagen IV (gelatin) were performed by surface plasmon resonance (SPR) and circular dichroism (CD) measurements. The ...

MFCD00009636

1-{[3-(2-Pyridinyldisulfanyl)propanoyl]oxy}-2,5-pyrrolidinedione

EINECS 269-034-3

N-succinimidyl 3-(2-pyridyldithio)-propionate

(2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate

1-{[3-(Pyridin-2-yldisulfanyl)propanoyl]oxy}pyrrolidine-2,5-dione

2,5-Pyrrolidinedione, 1-[1-oxo-3-(2-pyridinyldithio)propoxy]-

1-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2,5-dione

2,5-Pyrrolidinedione, 1-(1-oxo-3-(2-pyridinyldithio)propoxy)-

SPDP

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SPDP
Price: Check
Purity: 97.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: SPDP
Price: ￥398.0/10mg ￥848.0/25mg ￥2528.0/100mg
Purity: 95.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: SPDP
Price: $150.0/100mg $300.0/250mg $600.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: SPDP
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: SPDP
Price: ￥Inquiry/100mg ￥Inquiry/10mg ￥Inquiry/1g ￥Inquiry/250mg
Purity: 97.0%
Delivery: Inquiry
Contact: Xiyao Wang
Email: 3623107365@qq.com

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SPDP suppliers

Price: $66/10mM*1mLinDMSO

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SPDP

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