SPDP
SPDP structure
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Common Name | SPDP | ||
|---|---|---|---|---|
| CAS Number | 68181-17-9 | Molecular Weight | 312.365 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 465.9±55.0 °C at 760 mmHg | |
| Molecular Formula | C12H12N2O4S2 | Melting Point | 84-86 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 235.6±31.5 °C | |
Use of SPDPSPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP . |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | N-Succinimidyl 3-(2-Pyridyldithio)propionate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP . |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 465.9±55.0 °C at 760 mmHg |
| Melting Point | 84-86 °C(lit.) |
| Molecular Formula | C12H12N2O4S2 |
| Molecular Weight | 312.365 |
| Flash Point | 235.6±31.5 °C |
| Exact Mass | 312.023834 |
| PSA | 127.17000 |
| LogP | 0.99 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.650 |
| InChIKey | JWDFQMWEFLOOED-UHFFFAOYSA-N |
| SMILES | O=C(CCSSc1ccccn1)ON1C(=O)CCC1=O |
| Storage condition | −20°C |
| Water Solubility | acetone: 50 mg/mL |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~79%
SPDP CAS#:68181-17-9 |
| Literature: Shval'e, A. F.; Ofitserov, V. I.; Samukov, V. V. J. Gen. Chem. USSR (Engl. Transl.), 1985 , vol. 55, # 9 p. 2152,1909 - 1910 |
|
~74%
SPDP CAS#:68181-17-9 |
| Literature: Loccufier, J.; Schacht, E. Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 7 p. 535 - 540 |
|
~%
SPDP CAS#:68181-17-9 |
| Literature: Journal of the American Chemical Society, , vol. 129, # 31 p. 9640 - 9649 |
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~%
Detail
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| Literature: US4149003 A1, ; |
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~%
SPDP CAS#:68181-17-9 |
| Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 55, # 9 p. 2152,1909 - 1910 |
|
~%
SPDP CAS#:68181-17-9 |
| Literature: Bulletin des Societes Chimiques Belges, , vol. 97, # 7 p. 535 - 540 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 6 | |
|---|---|
| DownStream 0 | |
This table lists relevant public references with title, journal and publication metadata for this compound.
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This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| MFCD00009636 |
| 1-{[3-(2-Pyridinyldisulfanyl)propanoyl]oxy}-2,5-pyrrolidinedione |
| EINECS 269-034-3 |
| N-succinimidyl 3-(2-pyridyldithio)-propionate |
| (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate |
| 1-{[3-(Pyridin-2-yldisulfanyl)propanoyl]oxy}pyrrolidine-2,5-dione |
| 1-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2,5-dione |
| SPDP |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the safety information for N-Succinimidyl 3-(2-Pyridyldithio)propionate? |
| A: Safety information for N-Succinimidyl 3-(2-Pyridyldithio)propionate: S26-S36. |
| Q: What are the upstream materials of N-Succinimidyl 3-(2-Pyridyldithio)propionate? |
| A: Related upstream materials(CAS) of N-Succinimidyl 3-(2-Pyridyldithio)propionate: 6066-82-6;68617-64-1;2127-03-9;2637-34-5;107-96-0;59089-57-5. |
| Q: What is the InChIKey of N-Succinimidyl 3-(2-Pyridyldithio)propionate? |
| A: InChIKey of N-Succinimidyl 3-(2-Pyridyldithio)propionate is JWDFQMWEFLOOED-UHFFFAOYSA-N. |
| Q: What is the molecular formula of N-Succinimidyl 3-(2-Pyridyldithio)propionate? |
| A: Molecular formula of N-Succinimidyl 3-(2-Pyridyldithio)propionate is C12H12N2O4S2. |
| Q: What English synonyms does N-Succinimidyl 3-(2-Pyridyldithio)propionate have? |
| A: English synonyms of N-Succinimidyl 3-(2-Pyridyldithio)propionate: MFCD00009636, 1-{[3-(2-Pyridinyldisulfanyl)propanoyl]oxy}-2,5-pyrrolidinedione, EINECS 269-034-3, N-succinimidyl 3-(2-pyridyldithio)-propionate, (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate, 1-{[3-(Pyridin-2-yldisulfanyl)propanoyl]oxy}pyrrolidine-2,5-dione, 1-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2,5-dione, SPDP. |
| Q: What is the melting point of N-Succinimidyl 3-(2-Pyridyldithio)propionate? |
| A: Melting point of N-Succinimidyl 3-(2-Pyridyldithio)propionate is 84-86 °C(lit.). |
| Q: What is the polar surface area (PSA) of N-Succinimidyl 3-(2-Pyridyldithio)propionate? |
| A: Polar surface area (PSA) of N-Succinimidyl 3-(2-Pyridyldithio)propionate is 127.17000. |
| Q: How is the water solubility of N-Succinimidyl 3-(2-Pyridyldithio)propionate? |
| A: Water solubility of N-Succinimidyl 3-(2-Pyridyldithio)propionate: acetone: 50 mg/mL. |
| Q: What is the molecular weight of N-Succinimidyl 3-(2-Pyridyldithio)propionate? |
| A: Molecular weight of N-Succinimidyl 3-(2-Pyridyldithio)propionate is 312.365. |
| Q: What is the LogP of N-Succinimidyl 3-(2-Pyridyldithio)propionate? |
| A: LogP of N-Succinimidyl 3-(2-Pyridyldithio)propionate is 0.99. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |