158913-22-5
158913-22-5 structure
- Name: SPDP-C6-NHS ester
- Chemical Name: (2,5-dioxopyrrolidin-1-yl) 6-[3-(pyridin-2-yldisulfanyl)propanoylamino]hexanoate
- CAS Number: 158913-22-5
- Molecular Formula: C18H23N3O5S2
- Molecular Weight: 425.52200
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2016-09-28 06:11:36
- Modify Date: 2024-01-10 20:42:21
-
SPDP-C6-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | (2,5-dioxopyrrolidin-1-yl) 6-[3-(pyridin-2-yldisulfanyl)propanoylamino]hexanoate |
|---|---|
| Synonyms |
lc-spdp
spdph bicl208 |
| Description | SPDP-C6-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.36g/cm3 |
|---|---|
| Melting Point | 82-84ºC |
| Molecular Formula | C18H23N3O5S2 |
| Molecular Weight | 425.52200 |
| Exact Mass | 425.10800 |
| PSA | 156.27000 |
| LogP | 2.82460 |
| Index of Refraction | 1.61 |